======= ACADVL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACADVL
  * **<color #00a2e8>Official Name</color>**: acyl-CoA dehydrogenase very long chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=37|37]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49748|P49748]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACADVL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACADVL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609575|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons. {ECO:0000269|PubMed:18227065}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acyl-CoA dh 2|
|Acyl-CoA dh M|
|Acyl-CoA dh 1|
|Acyl-CoA dh N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|very-long-chain-acyl-CoA dehydrogenase activity|
|long-chain-acyl-CoA dehydrogenase activity|
|negative regulation of fatty acid oxidation|
|fatty acid beta-oxidation using acyl-CoA dehydrogenase|
|negative regulation of fatty acid biosynthetic process|
|fatty-acyl-CoA binding|
|negative regulation of fatty acid metabolic process|
|temperature homeostasis|
|regulation of fatty acid oxidation|
|mitochondrial nucleoid|
|regulation of fatty acid biosynthetic process|
|response to cold|
|negative regulation of lipid biosynthetic process|
|IRE1-mediated unfolded protein response|
|regulation of cholesterol metabolic process|
|fatty acid beta-oxidation|
|flavin adenine dinucleotide binding|
|fatty acid oxidation|
|lipid oxidation|
|negative regulation of lipid metabolic process|
|regulation of fatty acid metabolic process|
|negative regulation of small molecule metabolic process|
|fatty acid catabolic process|
|mitochondrial membrane|
|endoplasmic reticulum unfolded protein response|
|regulation of steroid metabolic process|
|monocarboxylic acid catabolic process|
|cellular response to unfolded protein|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|regulation of cellular ketone metabolic process|
|response to temperature stimulus|
|regulation of lipid biosynthetic process|
|response to topologically incorrect protein|
|cellular lipid catabolic process|
|lipid modification|
|energy derivation by oxidation of organic compounds|
|response to endoplasmic reticulum stress|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|lipid catabolic process|
|fatty acid metabolic process|
|multicellular organismal homeostasis|
|mitochondrial matrix|
|mitochondrial inner membrane|
|regulation of lipid metabolic process|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|small molecule catabolic process|
|monocarboxylic acid metabolic process|
|epithelial cell differentiation|
|nucleolus|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|epithelium development|
|response to abiotic stimulus|
|lipid metabolic process|
|mitochondrion|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|homeostatic process|
|cellular response to stress|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5408
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACADVL Expression in NALM6 Cells: 6.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>