======= ACE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACE
  * **<color #00a2e8>Official Name</color>**: angiotensin I converting enzyme
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1636|1636]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12821|P12821]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/106180|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of gap junction assembly|
|cell proliferation in bone marrow|
|regulation of angiotensin metabolic process|
|positive regulation of peptidyl-cysteine S-nitrosylation|
|bradykinin receptor binding|
|tripeptidyl-peptidase activity|
|regulation of renal output by angiotensin|
|peptidyl-dipeptidase activity|
|metallodipeptidase activity|
|regulation of gap junction assembly|
|positive regulation of peptidyl-tyrosine autophosphorylation|
|regulation of peptidyl-tyrosine autophosphorylation|
|exopeptidase activity|
|regulation of peptidyl-cysteine S-nitrosylation|
|regulation of blood volume by renin-angiotensin|
|regulation of hematopoietic stem cell proliferation|
|angiotensin maturation|
|regulation of angiotensin levels in blood|
|mitogen-activated protein kinase kinase binding|
|hematopoietic stem cell differentiation|
|chloride ion binding|
|positive regulation of systemic arterial blood pressure|
|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|
|dipeptidyl-peptidase activity|
|carboxypeptidase activity|
|hormone catabolic process|
|amyloid-beta metabolic process|
|mitogen-activated protein kinase binding|
|negative regulation of cell junction assembly|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|arachidonic acid secretion|
|arachidonate transport|
|positive regulation of protein autophosphorylation|
|icosanoid secretion|
|peptide catabolic process|
|fatty acid derivative transport|
|icosanoid transport|
|blood vessel remodeling|
|peptide hormone processing|
|positive regulation of blood pressure|
|regulation of systemic arterial blood pressure by hormone|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|regulation of protein autophosphorylation|
|endocrine process|
|positive regulation of protein tyrosine kinase activity|
|drug binding|
|regulation of vasoconstriction|
|long-chain fatty acid transport|
|regulation of smooth muscle cell migration|
|metallopeptidase activity|
|regulation of stem cell proliferation|
|fatty acid transport|
|endopeptidase activity|
|acid secretion|
|mononuclear cell proliferation|
|hematopoietic progenitor cell differentiation|
|heart contraction|
|regulation of protein tyrosine kinase activity|
|regulation of cell junction assembly|
|regulation of systemic arterial blood pressure|
|positive regulation of protein binding|
|leukocyte proliferation|
|antigen processing and presentation of peptide antigen via MHC class I|
|heart process|
|tissue remodeling|
|negative regulation of protein binding|
|monocarboxylic acid transport|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|stem cell differentiation|
|protein processing|
|vascular process in circulatory system|
|negative regulation of binding|
|positive regulation of binding|
|regulation of blood pressure|
|positive regulation of peptidyl-tyrosine phosphorylation|
|antigen processing and presentation of peptide antigen|
|hormone metabolic process|
|antigen processing and presentation|
|regulation of protein binding|
|protein maturation|
|lysosome|
|regulation of peptidyl-tyrosine phosphorylation|
|kidney development|
|endosome|
|renal system development|
|regulation of blood circulation|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|urogenital system development|
|lipid localization|
|regulation of binding|
|blood circulation|
|external side of plasma membrane|
|circulatory system process|
|regulation of hemopoiesis|
|organic anion transport|
|neutrophil mediated immunity|
|regulation of anatomical structure size|
|myeloid leukocyte mediated immunity|
|posttranscriptional regulation of gene expression|
|peptide metabolic process|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|spermatogenesis|
|cell population proliferation|
|hemopoiesis|
|male gamete generation|
|positive regulation of kinase activity|
|anion transport|
|regulation of system process|
|hematopoietic or lymphoid organ development|
|immune system development|
|positive regulation of transferase activity|
|gamete generation|
|negative regulation of cellular component organization|
|leukocyte mediated immunity|
|cellular amide metabolic process|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|immune effector process|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of protein modification process|
|proteolysis|
|ion transport|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|extracellular region|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.82|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.7|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9375
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACE Expression in NALM6 Cells: 1.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>