======= ACTR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACTR3
  * **<color #00a2e8>Official Name</color>**: actin related protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10096|10096]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61158|P61158]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACTR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACTR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604222|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. {ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:9000076}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Actin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|meiotic chromosome movement towards spindle pole|
|chromosome movement towards spindle pole|
|actin polymerization-dependent cell motility|
|meiotic cytokinesis|
|Arp2/3 protein complex|
|actin cortical patch|
|asymmetric cell division|
|Arp2/3 complex-mediated actin nucleation|
|actin nucleation|
|spindle localization|
|brush border|
|site of double-strand break|
|establishment of chromosome localization|
|chromosome localization|
|ephrin receptor signaling pathway|
|meiotic chromosome segregation|
|positive regulation of actin filament polymerization|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|structural constituent of cytoskeleton|
|positive regulation of protein polymerization|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|meiotic nuclear division|
|cellular response to interferon-gamma|
|regulation of actin filament polymerization|
|meiotic cell cycle process|
|cell-cell junction|
|lamellipodium|
|response to interferon-gamma|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|actin filament binding|
|actin cytoskeleton|
|nuclear chromosome segregation|
|positive regulation of cytoskeleton organization|
|meiotic cell cycle|
|regulation of protein polymerization|
|actin filament organization|
|Fc receptor signaling pathway|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|microtubule-based movement|
|chromosome segregation|
|nuclear division|
|organelle fission|
|phagocytosis|
|regulation of actin cytoskeleton organization|
|cilium assembly|
|regulation of supramolecular fiber organization|
|establishment of organelle localization|
|cilium organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|focal adhesion|
|plasma membrane bounded cell projection assembly|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|immune response-regulating cell surface receptor signaling pathway|
|cell division|
|actin cytoskeleton organization|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|immune response-activating signal transduction|
|actin filament-based process|
|organelle localization|
|immune response-regulating signaling pathway|
|positive regulation of organelle organization|
|activation of immune response|
|microtubule-based process|
|enzyme linked receptor protein signaling pathway|
|organelle assembly|
|innate immune response|
|membrane organization|
|positive regulation of immune response|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell cycle process|
|cellular response to cytokine stimulus|
|cell motility|
|localization of cell|
|immune effector process|
|response to cytokine|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|cell cycle|
|reproductive process|
|reproduction|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|establishment of localization in cell|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.92|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.84|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.51|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.28|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.89|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.87|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.82|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.77|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.76|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.7|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.72|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.77|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.95|
|[[:results:exp302|35°C R06 exp302]]|2.01|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.2|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:arpc4|ARPC4]]|0.678|
|[[:human genes:a:arpc2|ARPC2]]|0.673|
|[[:human genes:c:commd5|COMMD5]]|0.618|
|[[:human genes:c:commd3|COMMD3]]|0.581|
|[[:human genes:c:commd7|COMMD7]]|0.549|
|[[:human genes:c:ccdc22|CCDC22]]|0.531|
|[[:human genes:a:actr2|ACTR2]]|0.529|
|[[:human genes:c:commd9|COMMD9]]|0.513|
|[[:human genes:k:kiaa0196|KIAA0196]]|0.503|
|[[:human genes:c:ccdc53|CCDC53]]|0.485|
|[[:human genes:c:commd2|COMMD2]]|0.479|
|[[:human genes:r:rab7a|RAB7A]]|0.457|
|[[:human genes:v:vps29|VPS29]]|0.452|
|[[:human genes:v:vps45|VPS45]]|0.426|
|[[:human genes:c:commd10|COMMD10]]|0.423|
|[[:human genes:k:kiaa1033|KIAA1033]]|0.411|
|[[:human genes:m:mtmr9|MTMR9]]|0.406|
|[[:human genes:h:hgs|HGS]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2936
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACTR3 Expression in NALM6 Cells: 7.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>