======= ADAMTS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADAMTS1
  * **<color #00a2e8>Official Name</color>**: ADAM metallopeptidase with thrombospondin type 1 motif 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9510|9510]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHI8|Q9UHI8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADAMTS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADAMTS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605174|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. {ECO:0000250, ECO:0000269|PubMed:10438512}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADAM spacer1|
|Pep M12B propep|
|TSP 1|
|Reprolysin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ovulation from ovarian follicle|
|heart trabecula formation|
|positive regulation of vascular associated smooth muscle cell migration|
|ovulation|
|regulation of vascular associated smooth muscle cell migration|
|trabecula formation|
|heart trabecula morphogenesis|
|positive regulation of vascular smooth muscle cell proliferation|
|positive regulation of G1/S transition of mitotic cell cycle|
|positive regulation of smooth muscle cell migration|
|ovulation cycle process|
|trabecula morphogenesis|
|positive regulation of cell cycle G1/S phase transition|
|regulation of vascular smooth muscle cell proliferation|
|regulation of smooth muscle cell migration|
|metallopeptidase activity|
|ovulation cycle|
|positive regulation of mitotic cell cycle phase transition|
|positive regulation of smooth muscle cell proliferation|
|female gonad development|
|basement membrane|
|development of primary female sexual characteristics|
|positive regulation of cell cycle phase transition|
|integrin-mediated signaling pathway|
|metalloendopeptidase activity|
|female sex differentiation|
|cardiac chamber morphogenesis|
|female gamete generation|
|regulation of smooth muscle cell proliferation|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|heparin binding|
|cardiac chamber development|
|gonad development|
|development of primary sexual characteristics|
|heart morphogenesis|
|cytoplasmic vesicle|
|sex differentiation|
|kidney development|
|rhythmic process|
|renal system development|
|positive regulation of cell cycle process|
|urogenital system development|
|collagen-containing extracellular matrix|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|reproductive structure development|
|reproductive system development|
|regulation of cell cycle phase transition|
|positive regulation of cell migration|
|positive regulation of cell motility|
|heart development|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|regulation of mitotic cell cycle|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|gamete generation|
|regulation of cell cycle process|
|multicellular organismal reproductive process|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|regulation of locomotion|
|multi-organism reproductive process|
|regulation of cellular component movement|
|regulation of cell cycle|
|proteolysis|
|reproductive process|
|reproduction|
|regulation of cell population proliferation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.437|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8625
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADAMTS1 Expression in NALM6 Cells: 1.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>