======= ADCY1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADCY1
  * **<color #00a2e8>Official Name</color>**: adenylate cyclase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=107|107]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q08828|Q08828]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADCY1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADCY1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103072|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). {ECO:0000250|UniProtKB:O88444, ECO:0000250|UniProtKB:P19754}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Guanylate cyc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium- and calmodulin-responsive adenylate cyclase activity|
|adenylate cyclase activity|
|cAMP biosynthetic process|
|cellular response to forskolin|
|response to forskolin|
|response to platelet aggregation inhibitor|
|activation of protein kinase A activity|
|positive regulation of CREB transcription factor activity|
|positive regulation of long-term synaptic potentiation|
|response to lithium ion|
|cAMP metabolic process|
|cyclic purine nucleotide metabolic process|
|cyclic nucleotide biosynthetic process|
|cellular response to glucagon stimulus|
|long-term memory|
|hippocampal mossy fiber to CA3 synapse|
|renal water homeostasis|
|response to glucagon|
|activation of adenylate cyclase activity|
|neuroinflammatory response|
|cyclic nucleotide metabolic process|
|regulation of long-term synaptic potentiation|
|integral component of postsynaptic density membrane|
|multicellular organismal water homeostasis|
|water homeostasis|
|regulation of synaptic vesicle exocytosis|
|Schaffer collateral - CA1 synapse|
|cellular response to calcium ion|
|cellular response to alcohol|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|cellular response to ketone|
|regulation of neurotransmitter secretion|
|renal system process|
|regulation of synaptic vesicle cycle|
|regulation of circadian rhythm|
|memory|
|cellular response to antibiotic|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|circadian rhythm|
|regulation of neurotransmitter transport|
|cAMP-mediated signaling|
|purine ribonucleotide biosynthetic process|
|positive regulation of synaptic transmission|
|response to calcium ion|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|regulation of regulated secretory pathway|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|cyclic-nucleotide-mediated signaling|
|regulation of synaptic plasticity|
|cellular response to metal ion|
|response to ketone|
|calmodulin binding|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cellular response to inorganic substance|
|regulation of exocytosis|
|membrane raft|
|response to alcohol|
|nucleotide biosynthetic process|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|nucleoside phosphate biosynthetic process|
|learning or memory|
|positive regulation of DNA-binding transcription factor activity|
|cellular response to peptide hormone stimulus|
|rhythmic process|
|cognition|
|response to antibiotic|
|purine ribonucleotide metabolic process|
|multicellular organismal homeostasis|
|ribonucleotide metabolic process|
|cellular response to peptide|
|activation of protein kinase activity|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|purine-containing compound metabolic process|
|response to metal ion|
|axonogenesis|
|response to peptide hormone|
|cellular response to drug|
|axon development|
|regulation of DNA-binding transcription factor activity|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|response to peptide|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of body fluid levels|
|inflammatory response|
|cell part morphogenesis|
|cellular response to lipid|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|cellular response to organic cyclic compound|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|behavior|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|carbohydrate derivative biosynthetic process|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|neuron projection development|
|cell morphogenesis|
|brain development|
|regulation of secretion by cell|
|head development|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|response to lipid|
|regulation of kinase activity|
|organophosphate metabolic process|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of transferase activity|
|central nervous system development|
|response to organonitrogen compound|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|defense response|
|nervous system process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|generation of neurons|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cell development|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.74|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.17|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.21|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.36|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.758|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5435
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADCY1 Expression in NALM6 Cells: 4.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>