======= ADCY3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADCY3
  * **<color #00a2e8>Official Name</color>**: adenylate cyclase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=109|109]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60266|O60266]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADCY3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADCY3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600291|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. {ECO:0000250|UniProtKB:Q8VHH7}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Guanylate cyc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|olfactory learning|
|olfactory behavior|
|cAMP biosynthetic process|
|adenylate cyclase activity|
|response to forskolin|
|cellular response to forskolin|
|response to platelet aggregation inhibitor|
|chemosensory behavior|
|activation of protein kinase A activity|
|cAMP metabolic process|
|cyclic nucleotide biosynthetic process|
|acrosome reaction|
|cyclic purine nucleotide metabolic process|
|cellular response to glucagon stimulus|
|renal water homeostasis|
|response to glucagon|
|activation of adenylate cyclase activity|
|cyclic nucleotide metabolic process|
|multicellular organismal water homeostasis|
|flagellated sperm motility|
|sperm motility|
|water homeostasis|
|associative learning|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|cellular response to alcohol|
|cellular response to ketone|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|renal system process|
|cellular response to antibiotic|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|single fertilization|
|learning|
|cAMP-mediated signaling|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|fertilization|
|purine-containing compound biosynthetic process|
|cyclic-nucleotide-mediated signaling|
|response to ketone|
|cilium|
|calmodulin binding|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|response to alcohol|
|nucleotide biosynthetic process|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|nucleoside phosphate biosynthetic process|
|learning or memory|
|cellular response to peptide hormone stimulus|
|cognition|
|response to antibiotic|
|purine ribonucleotide metabolic process|
|multicellular organismal homeostasis|
|cellular response to peptide|
|ribonucleotide metabolic process|
|activation of protein kinase activity|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|purine-containing compound metabolic process|
|response to peptide hormone|
|cellular response to drug|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|sensory perception of smell|
|response to peptide|
|regulation of body fluid levels|
|cellular response to lipid|
|positive regulation of protein kinase activity|
|organophosphate biosynthetic process|
|sensory perception of chemical stimulus|
|nucleobase-containing small molecule metabolic process|
|cellular response to organic cyclic compound|
|behavior|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|carbohydrate derivative biosynthetic process|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulation of protein kinase activity|
|sexual reproduction|
|response to lipid|
|regulation of kinase activity|
|organophosphate metabolic process|
|response to hormone|
|response to organic cyclic compound|
|sensory perception|
|regulation of transferase activity|
|Golgi apparatus|
|multi-organism reproductive process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11357
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADCY3 Expression in NALM6 Cells: 5.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>