======= ADCY5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADCY5
  * **<color #00a2e8>Official Name</color>**: adenylate cyclase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=111|111]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95622|O95622]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADCY5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADCY5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600293|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). {ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:24700542, ECO:0000269|PubMed:24740569, ECO:0000269|PubMed:26206488}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1053|
|Guanylate cyc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenosine receptor signaling pathway|
|adenylate cyclase-inhibiting dopamine receptor signaling pathway|
|cAMP biosynthetic process|
|adenylate cyclase activity|
|adenylate cyclase-activating dopamine receptor signaling pathway|
|response to forskolin|
|cellular response to forskolin|
|adenylate cyclase binding|
|response to platelet aggregation inhibitor|
|activation of protein kinase A activity|
|G protein-coupled purinergic receptor signaling pathway|
|cAMP metabolic process|
|cyclic nucleotide biosynthetic process|
|cyclic purine nucleotide metabolic process|
|cellular response to glucagon stimulus|
|purinergic receptor signaling pathway|
|dopamine receptor signaling pathway|
|renal water homeostasis|
|response to glucagon|
|activation of adenylate cyclase activity|
|cyclic nucleotide metabolic process|
|intermediate filament cytoskeleton|
|neuromuscular process controlling balance|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|scaffold protein binding|
|multicellular organismal water homeostasis|
|water homeostasis|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|cellular response to alcohol|
|cellular response to dopamine|
|response to dopamine|
|cellular response to ketone|
|signal transduction involved in cellular response to ammonium ion|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|response to catecholamine|
|response to monoamine|
|neuromuscular process|
|renal system process|
|cellular response to antibiotic|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cellular response to ammonium ion|
|cAMP-mediated signaling|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|cyclic-nucleotide-mediated signaling|
|regulation of insulin secretion|
|response to ammonium ion|
|response to ketone|
|locomotory behavior|
|cilium|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of peptide hormone secretion|
|response to alcohol|
|nucleotide biosynthetic process|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|nucleoside phosphate biosynthetic process|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|positive regulation of cytosolic calcium ion concentration|
|response to antibiotic|
|purine ribonucleotide metabolic process|
|multicellular organismal homeostasis|
|cellular response to peptide|
|ribonucleotide metabolic process|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|purine-containing compound metabolic process|
|response to peptide hormone|
|cellular response to drug|
|cellular calcium ion homeostasis|
|nucleotide metabolic process|
|calcium ion homeostasis|
|nucleoside phosphate metabolic process|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of body fluid levels|
|cellular response to lipid|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|behavior|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|carbohydrate derivative biosynthetic process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|response to lipid|
|regulation of kinase activity|
|organophosphate metabolic process|
|cellular homeostasis|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of transferase activity|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7061
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADCY5 Expression in NALM6 Cells: 2.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>