======= ADCY8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADCY8
  * **<color #00a2e8>Official Name</color>**: adenylate cyclase 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114|114]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40145|P40145]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADCY8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADCY8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103070|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Guanylate cyc|
|DUF1053|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium- and calmodulin-responsive adenylate cyclase activity|
|sugar mediated signaling pathway|
|hexose mediated signaling|
|glucose mediated signaling pathway|
|cellular response to isoquinoline alkaloid|
|cellular response to morphine|
|carbohydrate mediated signaling|
|positive regulation of long-term synaptic depression|
|opioid receptor signaling pathway|
|adenylate cyclase activity|
|cAMP biosynthetic process|
|cellular response to forskolin|
|response to forskolin|
|positive regulation of synaptic plasticity|
|response to platelet aggregation inhibitor|
|regulation of long-term synaptic depression|
|activation of protein kinase A activity|
|positive regulation of CREB transcription factor activity|
|positive regulation of long-term synaptic potentiation|
|cAMP metabolic process|
|cyclic purine nucleotide metabolic process|
|cyclic nucleotide biosynthetic process|
|cellular response to glucagon stimulus|
|neuronal cell body membrane|
|plasma membrane raft|
|excitatory synapse|
|long-term memory|
|protein phosphatase 2A binding|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|response to morphine|
|response to isoquinoline alkaloid|
|hippocampal mossy fiber to CA3 synapse|
|renal water homeostasis|
|presynaptic active zone|
|cellular response to alkaloid|
|response to glucagon|
|activation of adenylate cyclase activity|
|neuroinflammatory response|
|cyclic nucleotide metabolic process|
|regulation of long-term synaptic potentiation|
|clathrin-coated vesicle membrane|
|clathrin-coated pit|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|integral component of presynaptic membrane|
|multicellular organismal water homeostasis|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|positive regulation of insulin secretion|
|water homeostasis|
|caveola|
|response to anesthetic|
|cellular response to carbohydrate stimulus|
|Schaffer collateral - CA1 synapse|
|cellular response to calcium ion|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|cellular response to alcohol|
|cellular glucose homeostasis|
|cellular response to ketone|
|positive regulation of peptide hormone secretion|
|renal system process|
|response to alkaloid|
|memory|
|cellular response to antibiotic|
|positive regulation of hormone secretion|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cellular response to ammonium ion|
|response to glucose|
|response to hexose|
|cAMP-mediated signaling|
|purine ribonucleotide biosynthetic process|
|response to monosaccharide|
|positive regulation of synaptic transmission|
|response to calcium ion|
|purine nucleotide biosynthetic process|
|protein dimerization activity|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|response to carbohydrate|
|cyclic-nucleotide-mediated signaling|
|regulation of insulin secretion|
|response to ammonium ion|
|glucose homeostasis|
|carbohydrate homeostasis|
|cellular response to xenobiotic stimulus|
|regulation of synaptic plasticity|
|cellular response to metal ion|
|response to ketone|
|locomotory behavior|
|basolateral plasma membrane|
|postsynaptic membrane|
|calmodulin binding|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of peptide hormone secretion|
|actin cytoskeleton|
|cellular response to inorganic substance|
|membrane raft|
|response to alcohol|
|nucleotide biosynthetic process|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|nucleoside phosphate biosynthetic process|
|postsynaptic density|
|learning or memory|
|positive regulation of DNA-binding transcription factor activity|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|actin binding|
|positive regulation of protein secretion|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|axon|
|cognition|
|response to xenobiotic stimulus|
|response to antibiotic|
|purine ribonucleotide metabolic process|
|apical plasma membrane|
|multicellular organismal homeostasis|
|ribonucleotide metabolic process|
|cellular response to peptide|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|protein homooligomerization|
|glutamatergic synapse|
|purine-containing compound metabolic process|
|response to metal ion|
|response to peptide hormone|
|positive regulation of secretion by cell|
|cellular response to drug|
|dendrite|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|nucleotide metabolic process|
|calcium ion homeostasis|
|nucleoside phosphate metabolic process|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of body fluid levels|
|inflammatory response|
|protein complex oligomerization|
|cellular response to lipid|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|cellular response to organic cyclic compound|
|cell junction|
|cellular metal ion homeostasis|
|behavior|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|carbohydrate derivative biosynthetic process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|response to lipid|
|regulation of kinase activity|
|protein homodimerization activity|
|organophosphate metabolic process|
|cellular homeostasis|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of transferase activity|
|positive regulation of transport|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|defense response|
|nervous system process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11516
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADCY8 Expression in NALM6 Cells: -5.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>