======= ADCYAP1R1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADCYAP1R1
  * **<color #00a2e8>Official Name</color>**: ADCYAP receptor type I
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=117|117]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41586|P41586]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADCYAP1R1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADCYAP1R1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102981|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HRM|
|7tm 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vasoactive intestinal polypeptide receptor activity|
|ADP-ribosylation factor binding|
|adenylate cyclase binding|
|positive regulation of inositol phosphate biosynthetic process|
|regulation of inositol phosphate biosynthetic process|
|neuropeptide binding|
|positive regulation of cAMP-mediated signaling|
|positive regulation of alcohol biosynthetic process|
|activation of phospholipase C activity|
|G protein-coupled peptide receptor activity|
|peptide hormone binding|
|positive regulation of phospholipase C activity|
|regulation of phospholipase C activity|
|regulation of cAMP-mediated signaling|
|positive regulation of calcium ion transport into cytosol|
|positive regulation of cellular carbohydrate metabolic process|
|positive regulation of phospholipase activity|
|rough endoplasmic reticulum|
|multicellular organismal response to stress|
|positive regulation of small GTPase mediated signal transduction|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|caveola|
|regulation of alcohol biosynthetic process|
|positive regulation of carbohydrate metabolic process|
|development of primary female sexual characteristics|
|regulation of carbohydrate biosynthetic process|
|regulation of lipase activity|
|regulation of calcium ion transport into cytosol|
|female sex differentiation|
|positive regulation of calcium ion transport|
|bicellular tight junction|
|response to ethanol|
|response to estradiol|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|signaling receptor activity|
|receptor complex|
|regulation of carbohydrate metabolic process|
|development of primary sexual characteristics|
|response to alcohol|
|regulation of calcium ion transport|
|sex differentiation|
|endosome|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|response to antibiotic|
|neuron projection|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|regulation of small GTPase mediated signal transduction|
|regulation of metal ion transport|
|regulation of small molecule metabolic process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|response to toxic substance|
|spermatogenesis|
|cellular metal ion homeostasis|
|male gamete generation|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|developmental process involved in reproduction|
|intracellular membrane-bounded organelle|
|gamete generation|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|positive regulation of transport|
|negative regulation of cell death|
|multi-organism reproductive process|
|positive regulation of intracellular signal transduction|
|response to drug|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.33|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.19|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.9|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.73|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.71|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.09|
|[[:results:exp461|BS-181 20μM R08 exp461]]|2.2|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.44|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.51|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.57|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.62|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.84|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.06|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.12|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.75|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|4.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17951
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADCYAP1R1 Expression in NALM6 Cells: -1.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>