======= ADRB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADRB3
  * **<color #00a2e8>Official Name</color>**: adrenoceptor beta 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=155|155]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13945|P13945]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADRB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADRB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109691|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|beta3-adrenergic receptor activity|
|beta-adrenergic receptor activity|
|norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure|
|desensitization of G protein-coupled receptor signaling pathway by arrestin|
|norepinephrine binding|
|epinephrine binding|
|regulation of systemic arterial blood pressure by norepinephrine-epinephrine|
|adrenergic receptor activity|
|negative regulation of systemic arterial blood pressure|
|negative adaptation of signaling pathway|
|desensitization of G protein-coupled receptor signaling pathway|
|adaptation of signaling pathway|
|adrenergic receptor signaling pathway|
|adenylate cyclase-activating adrenergic receptor signaling pathway|
|vasodilation|
|activation of adenylate cyclase activity|
|negative regulation of blood pressure|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|negative regulation of G protein-coupled receptor signaling pathway|
|positive regulation of blood vessel diameter|
|energy reserve metabolic process|
|regulation of systemic arterial blood pressure|
|positive regulation of cold-induced thermogenesis|
|negative regulation of protein binding|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of cold-induced thermogenesis|
|cAMP-mediated signaling|
|vascular process in circulatory system|
|negative regulation of binding|
|cyclic-nucleotide-mediated signaling|
|regulation of blood pressure|
|receptor complex|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of protein binding|
|energy derivation by oxidation of organic compounds|
|receptor-mediated endocytosis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|second-messenger-mediated signaling|
|regulation of binding|
|blood circulation|
|circulatory system process|
|generation of precursor metabolites and energy|
|carbohydrate metabolic process|
|regulation of anatomical structure size|
|positive regulation of MAPK cascade|
|endocytosis|
|import into cell|
|regulation of MAPK cascade|
|protein homodimerization activity|
|oxidation-reduction process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3976
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADRB3 Expression in NALM6 Cells: -1.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>