======= AHCY =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AHCY
  * **<color #00a2e8>Official Name</color>**: adenosylhomocysteinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=191|191]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23526|P23526]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AHCY&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AHCY|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180960|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. {ECO:0000269|PubMed:12590576}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AdoHcyase NAD|
|2-Hacid dh C|
|AdoHcyase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenyl nucleotide binding|
|S-adenosylhomocysteine catabolic process|
|chronic inflammatory response to antigenic stimulus|
|adenosylhomocysteinase activity|
|S-adenosylhomocysteine metabolic process|
|circadian sleep/wake cycle|
|S-adenosylmethionine cycle|
|purine ribonucleoside catabolic process|
|purine nucleoside catabolic process|
|chronic inflammatory response|
|S-adenosylmethionine metabolic process|
|circadian behavior|
|ribonucleoside catabolic process|
|inflammatory response to antigenic stimulus|
|rhythmic behavior|
|one-carbon metabolic process|
|cellular modified amino acid catabolic process|
|nucleoside catabolic process|
|NAD binding|
|sulfur amino acid metabolic process|
|glycosyl compound catabolic process|
|nucleobase-containing small molecule catabolic process|
|purine-containing compound catabolic process|
|sulfur compound catabolic process|
|cofactor catabolic process|
|purine ribonucleoside metabolic process|
|purine nucleoside metabolic process|
|ribonucleoside metabolic process|
|melanosome|
|alpha-amino acid catabolic process|
|nucleoside metabolic process|
|cellular amino acid catabolic process|
|glycosyl compound metabolic process|
|circadian rhythm|
|carbohydrate derivative catabolic process|
|cellular modified amino acid metabolic process|
|alpha-amino acid metabolic process|
|response to nutrient|
|coenzyme metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|rhythmic process|
|cellular amino acid metabolic process|
|methylation|
|neuron projection|
|response to hypoxia|
|response to decreased oxygen levels|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|nucleobase-containing compound catabolic process|
|response to oxygen levels|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|response to nutrient levels|
|inflammatory response|
|drug metabolic process|
|response to extracellular stimulus|
|nucleobase-containing small molecule metabolic process|
|behavior|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|response to abiotic stimulus|
|defense response|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.68|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-2.5|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.25|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.12|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.09|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.08|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.08|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.99|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.89|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.87|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.85|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.81|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.72|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.71|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.75|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.537|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 299/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|13/28|
|blood|19/28|
|bone|8/26|
|breast|22/33|
|central nervous system|11/56|
|cervix|3/4|
|colorectal|4/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|7/21|
|liver|6/20|
|lung|23/75|
|lymphocyte|10/16|
|ovary|6/26|
|pancreas|12/24|
|peripheral nervous system|4/16|
|plasma cell|12/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|6/22|
|urinary tract|11/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 49
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AHCY Expression in NALM6 Cells: 7.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>