======= AIM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AIM2
  * **<color #00a2e8>Official Name</color>**: absent in melanoma 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9447|9447]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14862|O14862]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AIM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AIM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604578|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. {ECO:0000250, ECO:0000269|PubMed:16432157, ECO:0000269|PubMed:17726700, ECO:0000269|PubMed:19158675, ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:19158679, ECO:0000269|PubMed:20566831}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAAD DAPIN|
|HIN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|AIM2 inflammasome complex|
|interleukin-1 beta secretion|
|pyroptosis|
|interleukin-1 secretion|
|interleukin-1 beta production|
|interleukin-1 production|
|cellular response to interferon-beta|
|positive regulation of protein oligomerization|
|positive regulation of defense response to virus by host|
|response to interferon-beta|
|positive regulation of interleukin-1 beta secretion|
|regulation of defense response to virus by host|
|positive regulation of interleukin-1 secretion|
|regulation of protein oligomerization|
|regulation of interleukin-1 beta secretion|
|cytokine secretion|
|positive regulation of interleukin-1 beta production|
|regulation of interleukin-1 secretion|
|positive regulation of interleukin-1 production|
|regulation of defense response to virus|
|regulation of interleukin-1 beta production|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of interleukin-1 production|
|double-stranded DNA binding|
|tumor necrosis factor-mediated signaling pathway|
|positive regulation of cytokine secretion|
|cytokine production|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of NF-kappaB transcription factor activity|
|protein secretion|
|establishment of protein localization to extracellular region|
|negative regulation of DNA-binding transcription factor activity|
|protein localization to extracellular region|
|positive regulation of endopeptidase activity|
|peptide secretion|
|positive regulation of peptidase activity|
|regulation of cytokine secretion|
|cellular response to tumor necrosis factor|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of protein complex assembly|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|positive regulation of innate immune response|
|positive regulation of proteolysis|
|positive regulation of response to biotic stimulus|
|cellular response to drug|
|positive regulation of secretion by cell|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of multi-organism process|
|positive regulation of cellular component biogenesis|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|activation of immune response|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|regulation of secretion|
|positive regulation of immune response|
|apoptotic process|
|defense response to other organism|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|secretion by cell|
|cellular response to cytokine stimulus|
|response to drug|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|identical protein binding|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|secretion|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of response to stress|
|protein transport|
|peptide transport|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|nitrogen compound transport|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13599
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AIM2 Expression in NALM6 Cells: -2.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>