======= AKR1B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKR1B1
  * **<color #00a2e8>Official Name</color>**: aldo-keto reductase family 1 member B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=231|231]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15121|P15121]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKR1B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKR1B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103880|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aldo ket red|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glyceraldehyde oxidoreductase activity|
|hexitol biosynthetic process|
|plasma membrane bounded cell projection cytoplasm|
|sorbitol biosynthetic process|
|cellular response to methylglyoxal|
|fructose biosynthetic process|
|naphthalene metabolic process|
|naphthalene-containing compound metabolic process|
|sorbitol metabolic process|
|Schwann cell microvillus|
|inner medullary collecting duct development|
|cellular hyperosmotic salinity response|
|response to methylglyoxal|
|hexitol metabolic process|
|allyl-alcohol dehydrogenase activity|
|alditol biosynthetic process|
|metanephric collecting duct development|
|retinal dehydrogenase activity|
|paranodal junction|
|cellular response to salt stress|
|polyketide metabolic process|
|daunorubicin metabolic process|
|doxorubicin metabolic process|
|response to water deprivation|
|hyperosmotic salinity response|
|aminoglycoside antibiotic metabolic process|
|cellular response to aldehyde|
|Schmidt-Lanterman incisure|
|cellular hyperosmotic response|
|NADP-retinol dehydrogenase activity|
|alcohol dehydrogenase (NADP+) activity|
|collecting duct development|
|norepinephrine metabolic process|
|tertiary alcohol metabolic process|
|alditol:NADP+ 1-oxidoreductase activity|
|C21-steroid hormone biosynthetic process|
|fructose metabolic process|
|response to water|
|glycoside metabolic process|
|regulation of urine volume|
|mast cell granule|
|response to salt stress|
|hyperosmotic response|
|alditol metabolic process|
|response to thyroid hormone|
|C21-steroid hormone metabolic process|
|quinone metabolic process|
|cellular response to osmotic stress|
|renal water homeostasis|
|retinol metabolic process|
|catecholamine metabolic process|
|catechol-containing compound metabolic process|
|steroid hormone biosynthetic process|
|hexose biosynthetic process|
|monosaccharide biosynthetic process|
|secondary metabolic process|
|cellular carbohydrate biosynthetic process|
|polyol biosynthetic process|
|hormone biosynthetic process|
|maternal process involved in female pregnancy|
|multicellular organismal water homeostasis|
|cellular ketone metabolic process|
|water homeostasis|
|electron transfer activity|
|primary alcohol metabolic process|
|response to osmotic stress|
|phenol-containing compound metabolic process|
|metanephros development|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of receptor signaling pathway via STAT|
|cellular response to ketone|
|retinoid metabolic process|
|antibiotic metabolic process|
|diterpenoid metabolic process|
|polyol metabolic process|
|renal system process|
|alcohol biosynthetic process|
|oxidoreductase activity|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|carbohydrate biosynthetic process|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of smooth muscle cell proliferation|
|glycosyl compound metabolic process|
|regulation of receptor signaling pathway via STAT|
|isoprenoid metabolic process|
|stress-activated protein kinase signaling cascade|
|hexose metabolic process|
|cellular carbohydrate metabolic process|
|female pregnancy|
|electron transport chain|
|organic hydroxy compound biosynthetic process|
|tissue homeostasis|
|response to ketone|
|ammonium ion metabolic process|
|monosaccharide metabolic process|
|hormone metabolic process|
|multi-multicellular organism process|
|steroid metabolic process|
|kidney development|
|renal system development|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|alcohol metabolic process|
|urogenital system development|
|multicellular organismal homeostasis|
|cellular response to peptide|
|anatomical structure homeostasis|
|response to acid chemical|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|response to peptide|
|carbohydrate metabolic process|
|regulation of body fluid levels|
|drug metabolic process|
|regulation of hormone levels|
|response to inorganic substance|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|perinuclear region of cytoplasm|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|cellular lipid metabolic process|
|oxidation-reduction process|
|negative regulation of cell death|
|multi-organism reproductive process|
|response to organonitrogen compound|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|response to abiotic stimulus|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|small molecule metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11779
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKR1B1 Expression in NALM6 Cells: 7.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>