======= AKR1B15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKR1B15
  * **<color #00a2e8>Official Name</color>**: aldo-keto reductase family 1 member B15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=441282|441282]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/C9JRZ8|C9JRZ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKR1B15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKR1B15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616336|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1: Mainly acts as a reductive enzyme that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Has a strong selectivity towards NADP(H) (PubMed:25577493). {ECO:0000269|PubMed:21276782, ECO:0000269|PubMed:25577493}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aldo ket red|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|farnesol dehydrogenase activity|
|testosterone 17-beta-dehydrogenase (NADP+) activity|
|allyl-alcohol dehydrogenase activity|
|estradiol 17-beta-dehydrogenase activity|
|NADP-retinol dehydrogenase activity|
|alcohol dehydrogenase (NADP+) activity|
|alditol:NADP+ 1-oxidoreductase activity|
|estrogen biosynthetic process|
|estrogen metabolic process|
|retinol metabolic process|
|steroid hormone biosynthetic process|
|hormone biosynthetic process|
|primary alcohol metabolic process|
|retinoid metabolic process|
|diterpenoid metabolic process|
|oxidoreductase activity|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|isoprenoid metabolic process|
|hormone metabolic process|
|steroid metabolic process|
|alcohol metabolic process|
|mitochondrial matrix|
|organic hydroxy compound metabolic process|
|regulation of hormone levels|
|lipid biosynthetic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|lipid metabolic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.77|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.89|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10811
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKR1B15 Expression in NALM6 Cells: 2.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>