======= AKR1C3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKR1C3
  * **<color #00a2e8>Official Name</color>**: aldo-keto reductase family 1 member C3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8644|8644]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42330|P42330]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKR1C3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKR1C3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603966|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aldo ket red|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ketoreductase activity|
|15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity|
|prostaglandin D2 11-ketoreductase activity|
|negative regulation of isoprenoid metabolic process|
|negative regulation of retinoic acid biosynthetic process|
|prostaglandin H2 endoperoxidase reductase activity|
|prostaglandin-F synthase activity|
|dihydrotestosterone 17-beta-dehydrogenase activity|
|farnesol metabolic process|
|sesquiterpenoid metabolic process|
|delta4-3-oxosteroid 5beta-reductase activity|
|geranylgeranyl reductase activity|
|regulation of retinoic acid biosynthetic process|
|farnesol catabolic process|
|sesquiterpenoid catabolic process|
|phenanthrene 9,10-monooxygenase activity|
|polyprenol catabolic process|
|regulation of testosterone biosynthetic process|
|indanol dehydrogenase activity|
|regulation of isoprenoid metabolic process|
|cellular response to jasmonic acid stimulus|
|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|
|testosterone 17-beta-dehydrogenase (NADP+) activity|
|response to jasmonic acid|
|testosterone dehydrogenase (NAD+) activity|
|response to prostaglandin D|
|testosterone biosynthetic process|
|androsterone dehydrogenase activity|
|cellular response to prostaglandin D stimulus|
|ketosteroid monooxygenase activity|
|negative regulation of vitamin metabolic process|
|terpenoid catabolic process|
|polyprenol metabolic process|
|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|
|retinal dehydrogenase activity|
|polyketide metabolic process|
|daunorubicin metabolic process|
|doxorubicin metabolic process|
|isoprenoid catabolic process|
|aminoglycoside antibiotic metabolic process|
|steroid dehydrogenase activity|
|aldo-keto reductase (NADP) activity|
|cyclooxygenase pathway|
|negative regulation of hormone metabolic process|
|NADP-retinol dehydrogenase activity|
|progesterone metabolic process|
|alcohol dehydrogenase (NADP+) activity|
|regulation of vitamin metabolic process|
|alditol:NADP+ 1-oxidoreductase activity|
|tertiary alcohol metabolic process|
|renal absorption|
|retinal metabolic process|
|primary alcohol catabolic process|
|regulation of ketone biosynthetic process|
|regulation of retinoic acid receptor signaling pathway|
|prostanoid biosynthetic process|
|positive regulation of endothelial cell apoptotic process|
|prostaglandin biosynthetic process|
|retinol dehydrogenase activity|
|glycoside metabolic process|
|cellular response to prostaglandin stimulus|
|regulation of hormone biosynthetic process|
|ketone biosynthetic process|
|C21-steroid hormone metabolic process|
|response to prostaglandin|
|quinone metabolic process|
|positive regulation of epithelial cell apoptotic process|
|prostanoid metabolic process|
|prostaglandin metabolic process|
|cellular response to cadmium ion|
|regulation of hormone metabolic process|
|retinol metabolic process|
|unsaturated fatty acid biosynthetic process|
|icosanoid biosynthetic process|
|steroid hormone biosynthetic process|
|negative regulation of lipid biosynthetic process|
|regulation of endothelial cell apoptotic process|
|antibiotic catabolic process|
|cellular aldehyde metabolic process|
|cellular response to fatty acid|
|secondary metabolic process|
|alcohol catabolic process|
|arachidonic acid metabolic process|
|cellular response to corticosteroid stimulus|
|hormone biosynthetic process|
|response to cadmium ion|
|cellular ketone metabolic process|
|organic hydroxy compound catabolic process|
|primary alcohol metabolic process|
|regulation of epithelial cell apoptotic process|
|negative regulation of lipid metabolic process|
|cellular response to calcium ion|
|cellular response to alcohol|
|response to fatty acid|
|regulation of steroid biosynthetic process|
|intracellular|
|negative regulation of small molecule metabolic process|
|cellular response to ketone|
|fatty acid derivative biosynthetic process|
|positive regulation of reactive oxygen species metabolic process|
|retinoid metabolic process|
|antibiotic metabolic process|
|unsaturated fatty acid metabolic process|
|diterpenoid metabolic process|
|renal system process|
|icosanoid metabolic process|
|regulation of steroid metabolic process|
|long-chain fatty acid metabolic process|
|oxidoreductase activity|
|fatty acid biosynthetic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|cellular response to reactive oxygen species|
|male gonad development|
|glycosyl compound metabolic process|
|development of primary male sexual characteristics|
|isoprenoid metabolic process|
|response to calcium ion|
|cellular response to starvation|
|male sex differentiation|
|response to corticosteroid|
|positive regulation of protein kinase B signaling|
|fatty acid derivative metabolic process|
|regulation of cellular ketone metabolic process|
|regulation of reactive oxygen species metabolic process|
|monocarboxylic acid biosynthetic process|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|cellular response to steroid hormone stimulus|
|cellular response to metal ion|
|response to starvation|
|response to ketone|
|ammonium ion metabolic process|
|response to reactive oxygen species|
|cellular lipid catabolic process|
|hormone metabolic process|
|cellular response to acid chemical|
|gonad development|
|response to nutrient|
|development of primary sexual characteristics|
|cellular response to inorganic substance|
|regulation of protein kinase B signaling|
|response to alcohol|
|cellular response to nutrient levels|
|cellular response to oxidative stress|
|steroid metabolic process|
|cellular response to extracellular stimulus|
|sex differentiation|
|keratinocyte differentiation|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|epidermal cell differentiation|
|alcohol metabolic process|
|fatty acid metabolic process|
|response to steroid hormone|
|cellular response to external stimulus|
|response to acid chemical|
|response to metal ion|
|skin development|
|response to oxidative stress|
|regulation of lipid metabolic process|
|epidermis development|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|small molecule catabolic process|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|response to nutrient levels|
|drug metabolic process|
|cellular response to lipid|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|regulation of hormone levels|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular response to hormone stimulus|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|positive regulation of cell death|
|response to lipid|
|response to hormone|
|carboxylic acid metabolic process|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|epithelium development|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12351
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKR1C3 Expression in NALM6 Cells: -0.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>