======= AKT1S1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKT1S1
  * **<color #00a2e8>Official Name</color>**: AKT1 substrate 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84335|84335]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96B36|Q96B36]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKT1S1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKT1S1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610221|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection. {ECO:0000269|PubMed:16174443, ECO:0000269|PubMed:17277771, ECO:0000269|PubMed:17386266}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TORC1 complex|
|negative regulation of cell size|
|neurotrophin TRK receptor signaling pathway|
|neurotrophin signaling pathway|
|negative regulation of TOR signaling|
|regulation of cellular response to heat|
|regulation of TOR signaling|
|regulation of cell size|
|regulation of neuron apoptotic process|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|regulation of neuron death|
|regulation of cellular component size|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|response to growth factor|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of transferase activity|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of cell death|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.99|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.474|
|[[:human genes:t:tceb3c|TCEB3C]]|0.473|
|[[:human genes:r:rps12|RPS12]]|0.471|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.466|
|[[:human genes:c:chd4|CHD4]]|0.466|
|[[:human genes:i:ik|IK]]|0.458|
|[[:human genes:t:tyms|TYMS]]|0.455|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.455|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.454|
|[[:human genes:r:rps2|RPS2]]|0.453|
|[[:human genes:n:nol10|NOL10]]|0.451|
|[[:human genes:a:aatf|AATF]]|0.45|
|[[:human genes:a:aamp|AAMP]]|0.444|
|[[:human genes:p:psmb2|PSMB2]]|0.443|
|[[:human genes:c:col2a1|COL2A1]]|0.441|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.438|
|[[:human genes:v:vps28|VPS28]]|0.436|
|[[:human genes:w:wdr87|WDR87]]|0.434|
|[[:human genes:s:slc4a1|SLC4A1]]|0.434|
|[[:human genes:r:rrp7a|RRP7A]]|0.433|
|[[:human genes:a:acbd4|ACBD4]]|0.433|
|[[:human genes:r:rps7|RPS7]]|0.433|
|[[:human genes:r:rpl6|RPL6]]|0.432|
|[[:human genes:c:cbwd3|CBWD3]]|0.432|
|[[:human genes:u:utp3|UTP3]]|0.431|
|[[:human genes:g:golga8o|GOLGA8O]]|0.43|
|[[:human genes:s:smtn|SMTN]]|0.43|
|[[:human genes:k:kif3c|KIF3C]]|0.43|
|[[:human genes:a:art5|ART5]]|0.429|
|[[:human genes:c:cdh24|CDH24]]|0.427|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.426|
|[[:human genes:c:cbwd5|CBWD5]]|0.421|
|[[:human genes:v:vasn|VASN]]|0.419|
|[[:human genes:e:exosc4|EXOSC4]]|0.418|
|[[:human genes:c:cbwd6|CBWD6]]|0.417|
|[[:human genes:d:disp2|DISP2]]|0.416|
|[[:human genes:c:copg1|COPG1]]|0.415|
|[[:human genes:r:rpl35|RPL35]]|0.414|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.413|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.413|
|[[:human genes:n:npipb5|NPIPB5]]|0.412|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.412|
|[[:human genes:p:prim1|PRIM1]]|0.41|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.41|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.41|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.409|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.409|
|[[:human genes:c:cep192|CEP192]]|0.408|
|[[:human genes:n:narfl|NARFL]]|0.407|
|[[:human genes:t:tuba8|TUBA8]]|0.407|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.406|
|[[:human genes:d:dhx38|DHX38]]|0.406|
|[[:human genes:p:psmc1|PSMC1]]|0.402|
|[[:human genes:t:timeless|TIMELESS]]|0.402|
|[[:human genes:p:polr2f|POLR2F]]|0.401|
|[[:human genes:n:nsf|NSF]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2227
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKT1S1 Expression in NALM6 Cells: 4.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>