======= ALDH3A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALDH3A1
  * **<color #00a2e8>Official Name</color>**: aldehyde dehydrogenase 3 family member A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=218|218]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30838|P30838]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALDH3A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALDH3A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/100660|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). {ECO:0000250|UniProtKB:P47739, ECO:0000269|PubMed:1737758, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LuxC|
|Aldedh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|benzaldehyde dehydrogenase (NAD+) activity|
|3-chloroallyl aldehyde dehydrogenase activity|
|aldehyde dehydrogenase [NAD(P)+] activity|
|alcohol dehydrogenase (NADP+) activity|
|aldehyde dehydrogenase (NAD) activity|
|cellular aldehyde metabolic process|
|response to cAMP|
|xenobiotic metabolic process|
|response to organophosphorus|
|response to glucocorticoid|
|response to purine-containing compound|
|response to corticosteroid|
|cellular response to xenobiotic stimulus|
|response to nutrient|
|aging|
|response to xenobiotic stimulus|
|response to steroid hormone|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|response to nutrient levels|
|response to extracellular stimulus|
|response to lipid|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|oxidation-reduction process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|response to drug|
|response to nitrogen compound|
|response to abiotic stimulus|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.71|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.71|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16684
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALDH3A1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>