======= ALOX12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALOX12
  * **<color #00a2e8>Official Name</color>**: arachidonate 12-lipoxygenase, 12S type
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=239|239]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18054|P18054]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALOX12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALOX12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/152391|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. {ECO:0000269|PubMed:16638750, ECO:0000269|PubMed:22237009, ECO:0000269|PubMed:23578768, ECO:0000269|PubMed:8250832, ECO:0000269|PubMed:9751607}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipoxygenase|
|PLAT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leukotriene A4 metabolic process|
|oxylipin metabolic process|
|lipoxin B4 metabolic process|
|lipoxin B4 biosynthetic process|
|lipoxin A4 biosynthetic process|
|positive regulation of endothelial tube morphogenesis|
|linoleate 13S-lipoxygenase activity|
|lipoxin A4 metabolic process|
|hepoxilin-epoxide hydrolase activity|
|arachidonate 12-lipoxygenase activity|
|epoxide metabolic process|
|hepoxilin metabolic process|
|hepoxilin biosynthetic process|
|lipoxin biosynthetic process|
|regulation of endothelial tube morphogenesis|
|lipoxin metabolic process|
|positive regulation of mitochondrial depolarization|
|negative regulation of platelet aggregation|
|positive regulation of membrane depolarization|
|negative regulation of homotypic cell-cell adhesion|
|lipoxygenase pathway|
|superoxide anion generation|
|ether metabolic process|
|linoleic acid metabolic process|
|regulation of platelet aggregation|
|negative regulation of platelet activation|
|regulation of mitochondrial depolarization|
|establishment of skin barrier|
|regulation of homotypic cell-cell adhesion|
|regulation of water loss via skin|
|long-chain fatty acid biosynthetic process|
|leukotriene metabolic process|
|regulation of platelet activation|
|positive regulation of morphogenesis of an epithelium|
|negative regulation of muscle cell apoptotic process|
|superoxide metabolic process|
|unsaturated fatty acid biosynthetic process|
|regulation of membrane depolarization|
|icosanoid biosynthetic process|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|positive regulation of blood vessel endothelial cell migration|
|arachidonic acid metabolic process|
|positive regulation of blood vessel diameter|
|multicellular organismal water homeostasis|
|regulation of muscle cell apoptotic process|
|regulation of mitochondrial membrane potential|
|negative regulation of wound healing|
|water homeostasis|
|fatty acid oxidation|
|lipid oxidation|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|positive regulation of smooth muscle cell proliferation|
|negative regulation of response to wounding|
|regulation of blood vessel endothelial cell migration|
|fatty acid derivative biosynthetic process|
|positive regulation of endothelial cell migration|
|sarcolemma|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|reactive oxygen species metabolic process|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|regulation of smooth muscle cell proliferation|
|iron ion binding|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of wound healing|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|positive regulation of epithelial cell migration|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of endothelial cell migration|
|fatty acid derivative metabolic process|
|regulation of response to wounding|
|vascular process in circulatory system|
|positive regulation of endopeptidase activity|
|negative regulation of cell-cell adhesion|
|regulation of morphogenesis of an epithelium|
|organic hydroxy compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|positive regulation of peptidase activity|
|negative regulation of cell activation|
|lipid modification|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of epithelial cell migration|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of cell adhesion|
|aging|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|multicellular organismal homeostasis|
|positive regulation of proteolysis|
|negative regulation of response to external stimulus|
|skin development|
|blood circulation|
|circulatory system process|
|regulation of cell-cell adhesion|
|regulation of endopeptidase activity|
|regulation of membrane potential|
|regulation of peptidase activity|
|organic hydroxy compound metabolic process|
|regulation of body fluid levels|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|cellular response to lipid|
|positive regulation of cell motility|
|monocarboxylic acid metabolic process|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of cell adhesion|
|positive regulation of cell death|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of cell migration|
|response to lipid|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cellular lipid metabolic process|
|oxidation-reduction process|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|oxoacid metabolic process|
|organic acid metabolic process|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|chemical homeostasis|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of molecular function|
|system process|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6374
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALOX12 Expression in NALM6 Cells: 0.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>