======= ALOX5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALOX5
  * **<color #00a2e8>Official Name</color>**: arachidonate 5-lipoxygenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=240|240]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09917|P09917]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALOX5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALOX5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/152390|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. {ECO:0000269|PubMed:21233389}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipoxygenase|
|PLAT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|arachidonate 5-lipoxygenase activity|
|arachidonic acid metabolite production involved in inflammatory response|
|leukotriene production involved in inflammatory response|
|lipoxin metabolic process|
|lipoxin biosynthetic process|
|cellular response to interleukin-18|
|interleukin-18-mediated signaling pathway|
|nuclear envelope lumen|
|response to interleukin-18|
|production of molecular mediator involved in inflammatory response|
|lipoxygenase pathway|
|leukotriene biosynthetic process|
|long-chain fatty acid biosynthetic process|
|leukotriene metabolic process|
|unsaturated fatty acid biosynthetic process|
|icosanoid biosynthetic process|
|fatty acid derivative biosynthetic process|
|unsaturated fatty acid metabolic process|
|nuclear matrix|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|secretory granule lumen|
|fatty acid biosynthetic process|
|ficolin-1-rich granule lumen|
|iron ion binding|
|fatty acid derivative metabolic process|
|nuclear envelope|
|monocarboxylic acid biosynthetic process|
|nuclear membrane|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|inflammatory response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cytokine-mediated signaling pathway|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|carboxylic acid metabolic process|
|leukocyte activation|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|secretion by cell|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|response to cytokine|
|secretion|
|lipid metabolic process|
|defense response|
|extracellular space|
|small molecule metabolic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9344
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALOX5 Expression in NALM6 Cells: 6.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>