======= ANGPTL4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANGPTL4
  * **<color #00a2e8>Official Name</color>**: angiopoietin like 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51129|51129]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BY76|Q9BY76]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANGPTL4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANGPTL4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605910|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12015030, ECO:0000269|PubMed:14583458}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fibrinogen C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of lipoprotein lipase activity|
|negative regulation of lipase activity|
|regulation of lipoprotein lipase activity|
|negative regulation of endothelial cell apoptotic process|
|enzyme inhibitor activity|
|triglyceride homeostasis|
|acylglycerol homeostasis|
|negative regulation of epithelial cell apoptotic process|
|regulation of endothelial cell apoptotic process|
|regulation of epithelial cell apoptotic process|
|regulation of lipase activity|
|lipid homeostasis|
|blood microparticle|
|positive regulation of angiogenesis|
|positive regulation of vasculature development|
|regulation of angiogenesis|
|angiogenesis|
|regulation of vasculature development|
|protein homooligomerization|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|negative regulation of hydrolase activity|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|protein complex oligomerization|
|tube morphogenesis|
|negative regulation of catalytic activity|
|tube development|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|chemical homeostasis|
|negative regulation of molecular function|
|response to abiotic stimulus|
|lipid metabolic process|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|extracellular space|
|homeostatic process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kctd17|KCTD17]]|0.451|
|[[:human genes:c:copg1|COPG1]]|0.411|
|[[:human genes:c:chd4|CHD4]]|0.406|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2576
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANGPTL4 Expression in NALM6 Cells: 0.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>