======= ANK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANK3
  * **<color #00a2e8>Official Name</color>**: ankyrin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=288|288]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12955|Q12955]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600465|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ZU5|
|Ank|
|Ank 2|
|Death|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maintenance of protein location in plasma membrane|
|maintenance of protein location in membrane|
|positive regulation of membrane depolarization during cardiac muscle cell action potential|
|positive regulation of cell communication by electrical coupling|
|regulation of membrane depolarization during cardiac muscle cell action potential|
|regulation of membrane depolarization during action potential|
|positive regulation of homotypic cell-cell adhesion|
|cellular response to magnesium ion|
|spectrin-associated cytoskeleton|
|protein localization to axon|
|positive regulation of action potential|
|cytoskeletal anchoring at plasma membrane|
|negative regulation of delayed rectifier potassium channel activity|
|negative regulation of voltage-gated potassium channel activity|
|magnesium ion homeostasis|
|positive regulation of membrane depolarization|
|regulation of cell communication by electrical coupling|
|node of Ranvier|
|positive regulation of membrane potential|
|positive regulation of sodium ion transmembrane transporter activity|
|costamere|
|regulation of delayed rectifier potassium channel activity|
|axon initial segment|
|negative regulation of potassium ion transmembrane transporter activity|
|response to magnesium ion|
|positive regulation of sodium ion transmembrane transport|
|negative regulation of potassium ion transmembrane transport|
|regulation of homotypic cell-cell adhesion|
|regulation of cardiac muscle cell action potential|
|spectrin binding|
|neuronal action potential|
|positive regulation of protein targeting to membrane|
|negative regulation of potassium ion transport|
|Golgi to plasma membrane protein transport|
|basal plasma membrane|
|positive regulation of sodium ion transport|
|membrane assembly|
|regulation of protein targeting to membrane|
|membrane biogenesis|
|neuromuscular junction development|
|T-tubule|
|negative regulation of cation channel activity|
|regulation of membrane depolarization|
|sarcoplasmic reticulum|
|intercalated disc|
|regulation of action potential|
|establishment of protein localization to plasma membrane|
|regulation of sodium ion transmembrane transporter activity|
|transmission of nerve impulse|
|regulation of potassium ion transmembrane transporter activity|
|lateral plasma membrane|
|Golgi to plasma membrane transport|
|regulation of sodium ion transmembrane transport|
|mitotic cytokinesis|
|positive regulation of cation channel activity|
|negative regulation of ion transmembrane transporter activity|
|maintenance of protein location in cell|
|cytoskeletal protein binding|
|neuromuscular junction|
|protein binding, bridging|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|negative regulation of cation transmembrane transport|
|regulation of protein targeting|
|regulation of sodium ion transport|
|plasma membrane organization|
|vesicle-mediated transport to the plasma membrane|
|action potential|
|maintenance of location in cell|
|regulation of potassium ion transport|
|negative regulation of ion transmembrane transport|
|cytoskeleton-dependent cytokinesis|
|sarcolemma|
|cytokinesis|
|post-Golgi vesicle-mediated transport|
|structural constituent of cytoskeleton|
|positive regulation of ion transmembrane transporter activity|
|maintenance of protein location|
|positive regulation of transporter activity|
|negative regulation of transmembrane transport|
|positive regulation of protein localization to membrane|
|bicellular tight junction|
|ion channel binding|
|Z disc|
|multicellular organismal signaling|
|positive regulation of cation transmembrane transport|
|negative regulation of ion transport|
|positive regulation of intracellular protein transport|
|positive regulation of ion transmembrane transport|
|maintenance of location|
|regulation of cation channel activity|
|protein localization to plasma membrane|
|regulation of protein localization to membrane|
|cellular response to metal ion|
|basolateral plasma membrane|
|postsynaptic membrane|
|positive regulation of transmembrane transport|
|positive regulation of intracellular transport|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|cellular response to inorganic substance|
|protein localization to cell periphery|
|regulation of intracellular protein transport|
|lysosome|
|positive regulation of cell-cell adhesion|
|regulation of ion transmembrane transporter activity|
|establishment of protein localization to membrane|
|regulation of transmembrane transporter activity|
|synapse organization|
|positive regulation of ion transport|
|regulation of transporter activity|
|cadherin binding|
|neuron projection|
|positive regulation of cellular protein localization|
|regulation of cation transmembrane transport|
|regulation of intracellular transport|
|response to metal ion|
|axonogenesis|
|Golgi vesicle transport|
|regulation of metal ion transport|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|axon development|
|endomembrane system organization|
|dendrite|
|positive regulation of protein transport|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of establishment of protein localization|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|cell projection morphogenesis|
|divalent inorganic cation homeostasis|
|cell division|
|cell part morphogenesis|
|response to inorganic substance|
|regulation of cellular protein localization|
|cell morphogenesis involved in differentiation|
|regulation of transmembrane transport|
|mitotic cell cycle process|
|cell surface|
|metal ion homeostasis|
|neuron projection development|
|regulation of cell adhesion|
|mitotic cell cycle|
|regulation of ion transport|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|ion homeostasis|
|neuron development|
|cellular component morphogenesis|
|membrane organization|
|regulation of cellular localization|
|Golgi apparatus|
|positive regulation of transport|
|cell cycle process|
|endoplasmic reticulum|
|neuron differentiation|
|regulation of protein localization|
|cytoskeleton organization|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|cell cycle|
|nervous system process|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of molecular function|
|positive regulation of cell communication|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|system process|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9616
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANK3 Expression in NALM6 Cells: 2.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>