======= ANP32A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANP32A
  * **<color #00a2e8>Official Name</color>**: acidic nuclear phosphoprotein 32 family member A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8125|8125]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P39687|P39687]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANP32A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANP32A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600832|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression. {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:17557114}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone binding|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of mRNA metabolic process|
|posttranscriptional regulation of gene expression|
|perinuclear region of cytoplasm|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|endoplasmic reticulum|
|RNA binding|
|intracellular transport|
|intracellular signal transduction|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.53|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.41|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.32|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.26|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.09|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.03|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.94|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.89|
|[[:results:exp539|42°C R08 exp539]]|-1.88|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.8|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.79|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.79|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.77|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.75|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.73|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.83|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.96|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.02|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.07|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.08|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.1|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|2.18|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.24|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.37|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.43|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.51|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.52|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kdm6a|KDM6A]]|0.625|
|[[:human genes:a:arid4b|ARID4B]]|0.571|
|[[:human genes:p:pds5b|PDS5B]]|0.551|
|[[:human genes:m:memo1|MEMO1]]|0.513|
|[[:human genes:i:itpk1|ITPK1]]|0.508|
|[[:human genes:e:esco1|ESCO1]]|0.468|
|[[:human genes:p:pcgf1|PCGF1]]|0.467|
|[[:human genes:i:ipmk|IPMK]]|0.463|
|[[:human genes:z:zbtb18|ZBTB18]]|0.46|
|[[:human genes:c:cnot2|CNOT2]]|0.46|
|[[:human genes:d:depdc5|DEPDC5]]|0.454|
|[[:human genes:y:ypel5|YPEL5]]|0.451|
|[[:human genes:r:rbm38|RBM38]]|0.448|
|[[:human genes:w:wdr26|WDR26]]|0.446|
|[[:human genes:u:uty|UTY]]|0.443|
|[[:human genes:u:ube2h|UBE2H]]|0.428|
|[[:human genes:f:fam122a|FAM122A]]|0.423|
|[[:human genes:p:prr14l|PRR14L]]|0.421|
|[[:human genes:p:poldip2|POLDIP2]]|0.417|
|[[:human genes:r:rbm26|RBM26]]|0.417|
|[[:human genes:k:kptn|KPTN]]|0.415|
|[[:human genes:s:szt2|SZT2]]|0.414|
|[[:human genes:a:anp32b|ANP32B]]|0.414|
|[[:human genes:c:cdk8|CDK8]]|0.413|
|[[:human genes:n:nprl2|NPRL2]]|0.411|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.409|
|[[:human genes:p:ptma|PTMA]]|0.409|
|[[:human genes:n:nprl3|NPRL3]]|0.409|
|[[:human genes:g:glyr1|GLYR1]]|0.409|
|[[:human genes:i:ippk|IPPK]]|0.408|
|[[:human genes:e:elmsan1|ELMSAN1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13237
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANP32A Expression in NALM6 Cells: 8.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>