======= AP2S1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AP2S1
  * **<color #00a2e8>Official Name</color>**: adaptor related protein complex 2 subunit sigma 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1175|1175]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53680|P53680]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AP2S1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AP2S1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602242|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). May also play a role in extracellular calcium homeostasis. {ECO:0000250, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23222959}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Clat adaptor s|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|clathrin adaptor activity|
|low-density lipoprotein particle receptor catabolic process|
|low-density lipoprotein receptor particle metabolic process|
|endolysosome membrane|
|AP-2 adaptor complex|
|clathrin coat assembly|
|low-density lipoprotein particle clearance|
|clathrin-dependent endocytosis|
|clathrin-coated endocytic vesicle|
|receptor catabolic process|
|regulation of defense response to virus by virus|
|clathrin-coated endocytic vesicle membrane|
|plasma lipoprotein particle clearance|
|endocytic vesicle membrane|
|regulation of plasma lipoprotein particle levels|
|ephrin receptor signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|receptor metabolic process|
|regulation of establishment of planar polarity|
|non-canonical Wnt signaling pathway|
|antigen processing and presentation of exogenous peptide antigen|
|regulation of morphogenesis of an epithelium|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|regulation of endocytosis|
|antigen processing and presentation|
|receptor-mediated endocytosis|
|regulation of animal organ morphogenesis|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of vesicle-mediated transport|
|endocytosis|
|cellular protein catabolic process|
|import into cell|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|viral process|
|enzyme linked receptor protein signaling pathway|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|membrane organization|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|cell-cell signaling|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.72|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vps8|VPS8]]|0.455|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.417|
|[[:human genes:s:sh3gl1|SH3GL1]]|0.416|
|[[:human genes:r:rab5c|RAB5C]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 316/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|12/28|
|blood|23/28|
|bone|5/26|
|breast|21/33|
|central nervous system|12/56|
|cervix|0/4|
|colorectal|7/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|10/21|
|liver|7/20|
|lung|32/75|
|lymphocyte|5/16|
|ovary|9/26|
|pancreas|14/24|
|peripheral nervous system|4/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|11/22|
|urinary tract|17/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 776
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AP2S1 Expression in NALM6 Cells: 5.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>