======= APBA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APBA1
  * **<color #00a2e8>Official Name</color>**: amyloid beta precursor protein binding family A member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=320|320]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02410|Q02410]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APBA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APBA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602414|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP- beta.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PID|
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gamma-aminobutyric acid secretion|
|gamma-aminobutyric acid transport|
|presynaptic active zone membrane|
|glutamate secretion|
|acidic amino acid transport|
|axo-dendritic transport|
|regulation of synaptic vesicle exocytosis|
|dicarboxylic acid transport|
|acid secretion|
|amyloid-beta binding|
|multicellular organism growth|
|Schaffer collateral - CA1 synapse|
|signal release from synapse|
|neurotransmitter secretion|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|amino acid transport|
|synaptic vesicle|
|monocarboxylic acid transport|
|regulation of neurotransmitter transport|
|dendritic spine|
|transport along microtubule|
|regulation of regulated secretory pathway|
|signal release|
|cytoskeleton-dependent intracellular transport|
|neurotransmitter transport|
|microtubule-based transport|
|locomotory behavior|
|regulation of exocytosis|
|synapse|
|microtubule-based movement|
|carboxylic acid transport|
|organic acid transport|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|in utero embryonic development|
|developmental growth|
|growth|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|regulation of vesicle-mediated transport|
|behavior|
|anion transport|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|microtubule-based process|
|perinuclear region of cytoplasm|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|embryo development|
|Golgi apparatus|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|ion transport|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.84|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.8|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|2.23|
|[[:results:exp148|SB202190 10μM R03 exp148]]|2.27|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|2.27|
|[[:results:exp124|GSK343 3μM R03 exp124]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3086
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APBA1 Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>