======= APC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APC2
  * **<color #00a2e8>Official Name</color>**: APC regulator of WNT signaling pathway 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10297|10297]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95996|O95996]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612034|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329). {ECO:0000269|PubMed:10021369, ECO:0000269|PubMed:11691822, ECO:0000269|PubMed:25753423, ECO:0000269|PubMed:9823329}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAMP|
|Arm|
|Suppressor APC|
|APC basic|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gamma-catenin binding|
|beta-catenin destruction complex|
|lamellipodium membrane|
|negative regulation of microtubule depolymerization|
|regulation of microtubule depolymerization|
|catenin complex|
|filamentous actin|
|negative regulation of microtubule polymerization or depolymerization|
|cytoplasmic microtubule|
|intercellular bridge|
|negative regulation of protein depolymerization|
|negative regulation of protein complex disassembly|
|regulation of microtubule polymerization or depolymerization|
|actin filament|
|regulation of protein depolymerization|
|postsynapse|
|beta-catenin binding|
|cell fate specification|
|activation of GTPase activity|
|regulation of protein complex disassembly|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|microtubule cytoskeleton|
|midbody|
|negative regulation of canonical Wnt signaling pathway|
|regulation of microtubule cytoskeleton organization|
|negative regulation of Wnt signaling pathway|
|positive regulation of protein catabolic process|
|regulation of microtubule-based process|
|microtubule binding|
|cell fate commitment|
|regulation of canonical Wnt signaling pathway|
|regulation of supramolecular fiber organization|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|negative regulation of organelle organization|
|regulation of protein catabolic process|
|positive regulation of GTPase activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|pattern specification process|
|microtubule cytoskeleton organization|
|regulation of GTPase activity|
|regulation of cytoskeleton organization|
|microtubule-based process|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|positive regulation of hydrolase activity|
|cell migration|
|Golgi apparatus|
|regulation of catabolic process|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|cell-cell signaling|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.7|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.82|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:art5|ART5]]|0.476|
|[[:human genes:d:dhx38|DHX38]]|0.469|
|[[:human genes:r:rpl35|RPL35]]|0.462|
|[[:human genes:p:polr2j3|POLR2J3]]|0.455|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.453|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.448|
|[[:human genes:p:palb2|PALB2]]|0.444|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.442|
|[[:human genes:l:loc643669|LOC643669]]|0.439|
|[[:human genes:f:fam25b|FAM25B]]|0.423|
|[[:human genes:n:nup85|NUP85]]|0.423|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.422|
|[[:human genes:a:akirin2|AKIRIN2]]|0.422|
|[[:human genes:k:kpnb1|KPNB1]]|0.421|
|[[:human genes:p:psmb2|PSMB2]]|0.418|
|[[:human genes:k:kctd17|KCTD17]]|0.418|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.417|
|[[:human genes:s:slc6a17|SLC6A17]]|0.414|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.41|
|[[:human genes:a:aqr|AQR]]|0.408|
|[[:human genes:c:cmya5|CMYA5]]|0.408|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.407|
|[[:human genes:r:rrp7a|RRP7A]]|0.406|
|[[:human genes:d:ddtl|DDTL]]|0.405|
|[[:human genes:r:rnf113a|RNF113A]]|0.402|
|[[:human genes:m:med14|MED14]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2312
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APC2 Expression in NALM6 Cells: 1.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>