======= AQP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AQP5
  * **<color #00a2e8>Official Name</color>**: aquaporin 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=362|362]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55064|P55064]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AQP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AQP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600442|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Aquaporin 5 (AQP5) is a water channel protein.  Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). {ECO:0000269|PubMed:16571723}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|carbon dioxide transport|
|saliva secretion|
|pancreatic juice secretion|
|cellular hypotonic response|
|hypotonic response|
|water channel activity|
|one-carbon compound transport|
|gas transport|
|water transport|
|secretion by tissue|
|fluid transport|
|basal plasma membrane|
|cellular response to osmotic stress|
|microvillus|
|digestive system process|
|body fluid secretion|
|response to osmotic stress|
|protein homotetramerization|
|digestion|
|camera-type eye morphogenesis|
|odontogenesis|
|cytoplasmic vesicle membrane|
|eye morphogenesis|
|drug transport|
|protein tetramerization|
|sensory organ morphogenesis|
|camera-type eye development|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|apical plasma membrane|
|protein homooligomerization|
|eye development|
|visual system development|
|sensory system development|
|regulation of body fluid levels|
|protein complex oligomerization|
|sensory organ development|
|animal organ morphogenesis|
|endoplasmic reticulum|
|response to drug|
|identical protein binding|
|secretion|
|response to abiotic stimulus|
|transmembrane transport|
|integral component of plasma membrane|
|protein-containing complex assembly|
|cellular response to stress|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7262
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AQP5 Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>