======= ARFRP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARFRP1
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor related protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10139|10139]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13795|Q13795]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARFRP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARFRP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604699|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. {ECO:0000250|UniProtKB:Q8BXL7}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SRPRB|
|Miro|
|Arf|
|Gtr1 RagA|
|G-alpha|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to Golgi apparatus|
|Golgi to plasma membrane protein transport|
|establishment of protein localization to plasma membrane|
|Golgi to plasma membrane transport|
|retrograde transport, endosome to Golgi|
|vesicle-mediated transport to the plasma membrane|
|trans-Golgi network membrane|
|post-Golgi vesicle-mediated transport|
|cytosolic transport|
|gastrulation|
|trans-Golgi network|
|protein localization to plasma membrane|
|endosomal transport|
|protein localization to cell periphery|
|establishment of protein localization to membrane|
|GTPase activity|
|Golgi vesicle transport|
|GTP binding|
|protein localization to membrane|
|embryonic morphogenesis|
|protein localization to organelle|
|embryo development|
|Golgi apparatus|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-3.29|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.68|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.55|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.54|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.53|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.49|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-2.41|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-2.28|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2.27|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.26|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.25|
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.22|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.21|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.19|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.18|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-2.18|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.13|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.11|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.08|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.08|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.06|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.06|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.05|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-2.04|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.03|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.98|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.96|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.96|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.94|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.94|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.93|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.89|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.88|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.88|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.87|
|[[:results:exp539|42°C R08 exp539]]|-1.86|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.84|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.84|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.83|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.83|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.83|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.82|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.82|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.82|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.82|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.81|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.81|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.81|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.81|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.78|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.78|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.78|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.78|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.76|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.74|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.73|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.72|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.71|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.47|
|[[:human genes:j:jtb|JTB]]|0.451|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 72/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|5/26|
|breast|2/33|
|central nervous system|3/56|
|cervix|2/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|0/16|
|kidney|1/21|
|liver|6/20|
|lung|7/75|
|lymphocyte|3/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|4/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 921
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARFRP1 Expression in NALM6 Cells: 4.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>