======= ARHGEF7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARHGEF7
  * **<color #00a2e8>Official Name</color>**: Rho guanine nucleotide exchange factor 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8874|8874]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14155|Q14155]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARHGEF7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARHGEF7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605477|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|RhoGEF|
|CH|
|PH|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of lamellipodium morphogenesis|
|regulation of lamellipodium morphogenesis|
|positive regulation of fibroblast migration|
|regulation of GTP binding|
|cell-substrate adherens junction assembly|
|focal adhesion assembly|
|positive regulation of lamellipodium organization|
|regulation of fibroblast migration|
|lamellipodium assembly|
|adherens junction assembly|
|positive regulation of substrate adhesion-dependent cell spreading|
|lamellipodium organization|
|regulation of lamellipodium organization|
|cell-substrate junction assembly|
|negative regulation of epidermal growth factor receptor signaling pathway|
|negative regulation of ERBB signaling pathway|
|regulation of substrate adhesion-dependent cell spreading|
|Rho guanyl-nucleotide exchange factor activity|
|regulation of epidermal growth factor receptor signaling pathway|
|adherens junction organization|
|ephrin receptor signaling pathway|
|regulation of ERBB signaling pathway|
|ruffle|
|guanyl-nucleotide exchange factor activity|
|positive regulation of cell-substrate adhesion|
|cell-matrix adhesion|
|Golgi organization|
|cell cortex|
|regulation of Rho protein signal transduction|
|positive regulation of cell morphogenesis involved in differentiation|
|cell junction assembly|
|lamellipodium|
|cell-substrate adhesion|
|regulation of cell-substrate adhesion|
|cell junction organization|
|regulation of Ras protein signal transduction|
|regulation of cell morphogenesis involved in differentiation|
|neuron projection|
|regulation of small GTPase mediated signal transduction|
|neuronal cell body|
|regulation of binding|
|positive regulation of cell projection organization|
|positive regulation of cell adhesion|
|positive regulation of GTPase activity|
|focal adhesion|
|endomembrane system organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein kinase binding|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of locomotion|
|protein-containing complex|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|positive regulation of hydrolase activity|
|regulation of cell migration|
|regulation of cell motility|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 73/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|4/20|
|lung|7/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|6/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|8/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14231
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARHGEF7 Expression in NALM6 Cells: 7.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>