======= ARID1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARID1A
  * **<color #00a2e8>Official Name</color>**: AT-rich interaction domain 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8289|8289]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14497|O14497]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARID1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARID1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603024|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3518|
|ARID|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleosome mobilization|
|optic cup formation involved in camera-type eye development|
|brahma complex|
|maintenance of chromatin silencing|
|glucocorticoid receptor signaling pathway|
|optic cup morphogenesis involved in camera-type eye development|
|corticosteroid receptor signaling pathway|
|chromatin-mediated maintenance of transcription|
|npBAF complex|
|embryonic camera-type eye formation|
|nBAF complex|
|nucleosome disassembly|
|chromatin disassembly|
|SWI/SNF complex|
|intracellular estrogen receptor signaling pathway|
|nuclear receptor binding|
|protein-DNA complex disassembly|
|embryonic camera-type eye morphogenesis|
|nucleosome binding|
|placenta blood vessel development|
|embryonic eye morphogenesis|
|androgen receptor signaling pathway|
|embryo implantation|
|embryonic camera-type eye development|
|toxin transport|
|chromatin organization involved in negative regulation of transcription|
|chromatin silencing|
|positive regulation of gene expression, epigenetic|
|intracellular steroid hormone receptor signaling pathway|
|chromatin organization involved in regulation of transcription|
|ATP-dependent chromatin remodeling|
|negative regulation of gene expression, epigenetic|
|cardiac muscle cell differentiation|
|neural tube closure|
|tube closure|
|primary neural tube formation|
|neural tube formation|
|formation of primary germ layer|
|camera-type eye morphogenesis|
|cardiocyte differentiation|
|steroid hormone mediated signaling pathway|
|embryonic epithelial tube formation|
|epithelial tube formation|
|stem cell population maintenance|
|maintenance of cell number|
|morphogenesis of embryonic epithelium|
|eye morphogenesis|
|tube formation|
|gene silencing|
|placenta development|
|chromatin assembly or disassembly|
|nucleosome organization|
|gastrulation|
|neural tube development|
|chromatin remodeling|
|cardiac muscle tissue development|
|intracellular receptor signaling pathway|
|cardiac chamber development|
|hormone-mediated signaling pathway|
|female pregnancy|
|cellular response to steroid hormone stimulus|
|striated muscle cell differentiation|
|multi-multicellular organism process|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|protein-containing complex disassembly|
|protein-DNA complex subunit organization|
|muscle cell differentiation|
|sensory organ morphogenesis|
|striated muscle tissue development|
|transcription coactivator activity|
|embryonic organ morphogenesis|
|muscle tissue development|
|epithelial tube morphogenesis|
|camera-type eye development|
|response to steroid hormone|
|eye development|
|visual system development|
|sensory system development|
|forebrain development|
|cellular component disassembly|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|muscle structure development|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|heart development|
|cellular response to organic cyclic compound|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|cellular response to hormone stimulus|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|chromatin organization|
|brain development|
|head development|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|response to organic cyclic compound|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|multi-organism reproductive process|
|chromosome organization|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.07|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.05|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.04|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.96|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.88|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.72|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.74|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.77|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.82|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.82|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.91|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.14|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.16|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.21|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.26|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.33|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.38|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.56|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|4.33|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|4.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:smarcc1|SMARCC1]]|0.489|
|[[:human genes:p:prdm15|PRDM15]]|0.426|
|[[:human genes:s:smarcb1|SMARCB1]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1854
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARID1A Expression in NALM6 Cells: 8.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>