======= ARID3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARID3A
  * **<color #00a2e8>Official Name</color>**: AT-rich interaction domain 3A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1820|1820]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99856|Q99856]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARID3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARID3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603265|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269|PubMed:11812999, ECO:0000269|PubMed:12692263}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ARID|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|G1 DNA damage checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in cell cycle checkpoint|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|mitotic DNA damage checkpoint|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|signal transduction by p53 class mediator|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of cell cycle G1/S phase transition|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|membrane raft|
|negative regulation of cell cycle phase transition|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|negative regulation of cell cycle process|
|positive regulation of cell cycle|
|chromatin binding|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|protein homodimerization activity|
|cell cycle process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|cell cycle|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.84|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.55|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.55|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.89|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.76|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.71|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.73|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.76|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.78|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.83|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.86|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.87|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.88|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.89|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.99|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.11|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.15|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2.28|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.35|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.39|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6141
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARID3A Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>