======= ARID4A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARID4A
  * **<color #00a2e8>Official Name</color>**: AT-rich interaction domain 4A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5926|5926]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29374|P29374]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARID4A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARID4A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180201|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Interacts with the viral protein-binding domain of the retinoblastoma protein.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RBB1NT|
|Tudor-knot|
|ARID|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of Sertoli cell barrier|
|histone H3-K9 trimethylation|
|histone H4-K20 trimethylation|
|histone H4-K20 methylation|
|Sertoli cell development|
|histone H3-K9 methylation|
|histone H3-K4 trimethylation|
|regulation of gene expression by genetic imprinting|
|histone H3-K9 modification|
|Sertoli cell differentiation|
|genetic imprinting|
|peptidyl-lysine trimethylation|
|erythrocyte development|
|histone H3-K4 methylation|
|transcriptional repressor complex|
|myeloid cell development|
|histone lysine methylation|
|erythrocyte differentiation|
|peptidyl-lysine methylation|
|erythrocyte homeostasis|
|histone methylation|
|myeloid cell homeostasis|
|male gonad development|
|protein alkylation|
|protein methylation|
|development of primary male sexual characteristics|
|male sex differentiation|
|epithelial cell development|
|homeostasis of number of cells|
|gonad development|
|development of primary sexual characteristics|
|transcription regulatory region DNA binding|
|myeloid cell differentiation|
|regulation of gene expression, epigenetic|
|macromolecule methylation|
|sex differentiation|
|methylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|reproductive structure development|
|reproductive system development|
|spermatogenesis|
|hemopoiesis|
|male gamete generation|
|hematopoietic or lymphoid organ development|
|immune system development|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|gamete generation|
|chromatin organization|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|peptidyl-amino acid modification|
|multi-organism reproductive process|
|chromosome organization|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-2.11|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.86|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.7|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.7|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.71|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.73|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.76|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.77|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.83|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.93|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.97|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.03|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.05|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.13|
|[[:results:exp453|B02 10μM R08 exp453]]|2.16|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.24|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.32|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2.4|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.47|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.49|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.5|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.63|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.8|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:arid4b|ARID4B]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18156
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARID4A Expression in NALM6 Cells: 5.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>