======= ARL13B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARL13B
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor like GTPase 13B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=200894|200894]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3SXY8|Q3SXY8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARL13B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARL13B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608922|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. This protein is localized in the cilia and plays a role in cilia formation and in maintenance of cilia. Mutations in this gene are the cause of Joubert syndrome 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidences are required to confirm these data. {ECO:0000269|PubMed:23150559}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Arf|
|SRPRB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|formation of radial glial scaffolds|
|receptor localization to non-motile cilium|
|protein localization to ciliary membrane|
|hindbrain radial glia guided cell migration|
|interneuron migration from the subpallium to the cortex|
|protein localization to non-motile cilium|
|substrate-independent telencephalic tangential interneuron migration|
|substrate-independent telencephalic tangential migration|
|left/right axis specification|
|cell migration in hindbrain|
|left/right pattern formation|
|response to lithium ion|
|non-motile cilium|
|neural tube patterning|
|non-motile cilium assembly|
|protein localization to cilium|
|ciliary membrane|
|telencephalon cell migration|
|heart looping|
|forebrain cell migration|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|smoothened signaling pathway|
|embryonic heart tube development|
|dorsal/ventral pattern formation|
|axis specification|
|motile cilium|
|axoneme|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|hindbrain development|
|neural tube development|
|cilium|
|protein localization to cell periphery|
|heart morphogenesis|
|telencephalon development|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|regionalization|
|cilium assembly|
|cilium organization|
|response to metal ion|
|forebrain development|
|GTP binding|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein localization to membrane|
|heart development|
|response to inorganic substance|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|cell morphogenesis|
|protein localization to organelle|
|brain development|
|organelle assembly|
|head development|
|cellular component morphogenesis|
|tube development|
|circulatory system development|
|animal organ morphogenesis|
|cell migration|
|embryo development|
|central nervous system development|
|cell motility|
|localization of cell|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|cell development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.71|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.72|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13562
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARL13B Expression in NALM6 Cells: 4.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>