======= ARL2BP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARL2BP
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor like GTPase 2 binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23568|23568]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2Y0|Q9Y2Y0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARL2BP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARL2BP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615407|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. {ECO:0000269|PubMed:18234692}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ARL2 Bind BART|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GTPase regulator activity|
|maintenance of protein location in nucleus|
|maintenance of protein localization in organelle|
|positive regulation of tyrosine phosphorylation of STAT protein|
|maintenance of protein location in cell|
|mitochondrial intermembrane space|
|regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of receptor signaling pathway via STAT|
|maintenance of location in cell|
|maintenance of protein location|
|spindle|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|midbody|
|protein localization to nucleus|
|maintenance of location|
|regulation of insulin secretion|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cilium|
|regulation of peptide hormone secretion|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of hormone secretion|
|transcription coactivator activity|
|mitochondrial matrix|
|regulation of protein secretion|
|centrosome|
|regulation of peptide secretion|
|regulation of hormone levels|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|regulation of protein phosphorylation|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.01|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5319
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARL2BP Expression in NALM6 Cells: 3.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>