======= ARL6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARL6
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor like GTPase 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84100|84100]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0F7|Q9H0F7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARL6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARL6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608845|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the ARF-like (ADP ribosylation factor-like) sub-family of the ARF family of GTP-binding proteins which are involved in regulation of intracellular traffic. Mutations in this gene are associated with Bardet-Biedl syndrome (BBS). A vision-specific transcript, encoding long isoform BBS3L, has been described (PMID: 20333246). [provided by RefSeq, Apr 2016]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (PubMed:20603001). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (PubMed:22072986). May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (PubMed:20207729). Isoform 2 may be required for proper retinal function and organization (By similarity). {ECO:0000250|UniProtKB:O88848, ECO:0000269|PubMed:20207729, ECO:0000269|PubMed:20603001, ECO:0000269|PubMed:22072986}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SRPRB|
|Arf|
|G-alpha|
|Gtr1 RagA|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein transport from ciliary membrane to plasma membrane|
|membrane coat|
|protein transport within lipid bilayer|
|axonemal microtubule|
|protein localization to non-motile cilium|
|melanosome transport|
|pigment granule transport|
|retina layer formation|
|establishment of melanosome localization|
|establishment of pigment granule localization|
|melanosome localization|
|pigment granule localization|
|protein localization to cilium|
|cellular pigmentation|
|retina morphogenesis in camera-type eye|
|establishment of protein localization to plasma membrane|
|neural retina development|
|regulation of smoothened signaling pathway|
|localization within membrane|
|protein polymerization|
|pigmentation|
|axoneme|
|phospholipid binding|
|fat cell differentiation|
|camera-type eye morphogenesis|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|retina development in camera-type eye|
|eye morphogenesis|
|protein targeting to membrane|
|establishment of vesicle localization|
|protein localization to plasma membrane|
|vesicle localization|
|cilium|
|visual perception|
|sensory perception of light stimulus|
|protein localization to cell periphery|
|sensory organ morphogenesis|
|establishment of protein localization to membrane|
|camera-type eye development|
|GTPase activity|
|cilium assembly|
|protein targeting|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|eye development|
|visual system development|
|establishment of organelle localization|
|cilium organization|
|sensory system development|
|GTP binding|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein localization to membrane|
|sensory organ development|
|organelle localization|
|protein localization to organelle|
|brain development|
|organelle assembly|
|head development|
|cellular protein-containing complex assembly|
|membrane organization|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|sensory perception|
|central nervous system development|
|intracellular protein transport|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|nervous system process|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp136|MS094 2μM R03 exp136]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18704
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARL6 Expression in NALM6 Cells: 2.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>