======= ATAT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATAT1
  * **<color #00a2e8>Official Name</color>**: alpha tubulin acetyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79969|79969]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5SQI0|Q5SQI0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATAT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATAT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615556|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:20829795, ECO:0000269|PubMed:21068373, ECO:0000269|PubMed:24097348, ECO:0000269|PubMed:24906155}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mec-17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tubulin N-acetyltransferase activity|
|alpha-tubulin acetylation|
|lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|
|microtubule bundle|
|positive regulation of NLRP3 inflammasome complex assembly|
|coenzyme binding|
|regulation of NLRP3 inflammasome complex assembly|
|dentate gyrus development|
|clathrin-coated pit|
|mitotic spindle|
|hippocampus development|
|limbic system development|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|regulation of fat cell differentiation|
|internal protein amino acid acetylation|
|protein acetylation|
|pallium development|
|protein acylation|
|regulation of microtubule cytoskeleton organization|
|regulation of microtubule-based process|
|positive regulation of protein complex assembly|
|telencephalon development|
|axon|
|peptidyl-lysine modification|
|microtubule|
|cilium assembly|
|cilium organization|
|forebrain development|
|focal adhesion|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|cell projection assembly|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|spermatogenesis|
|male gamete generation|
|gamete generation|
|brain development|
|organelle assembly|
|head development|
|neuron development|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|peptidyl-amino acid modification|
|regulation of cellular component biogenesis|
|central nervous system development|
|Golgi apparatus|
|multi-organism reproductive process|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|reproductive process|
|reproduction|
|generation of neurons|
|neurogenesis|
|cell development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.72|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.98|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.1|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.27|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|2.99|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|3.09|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|3.5|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|4.1|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|4.4|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|4.7|
|[[:results:exp59|UMK57 1μM R01 exp59]]|5.14|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|6.67|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tmem161b|TMEM161B]]|0.577|
|[[:human genes:a:atp1a1|ATP1A1]]|0.527|
|[[:human genes:s:setdb1|SETDB1]]|0.471|
|[[:human genes:a:arhgap11b|ARHGAP11B]]|0.466|
|[[:human genes:c:ccnf|CCNF]]|0.449|
|[[:human genes:n:numa1|NUMA1]]|0.446|
|[[:human genes:p:ppp1cc|PPP1CC]]|0.442|
|[[:human genes:n:nde1|NDE1]]|0.425|
|[[:human genes:p:pigf|PIGF]]|0.423|
|[[:human genes:a:aff1|AFF1]]|0.422|
|[[:human genes:p:ppp1ca|PPP1CA]]|0.421|
|[[:human genes:k:kif18b|KIF18B]]|0.419|
|[[:human genes:p:ppp1r2|PPP1R2]]|0.415|
|[[:human genes:p:prkar1a|PRKAR1A]]|0.412|
|[[:human genes:u:usp28|USP28]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13353
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATAT1 Expression in NALM6 Cells: 4.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>