======= ATF7IP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATF7IP
  * **<color #00a2e8>Official Name</color>**: activating transcription factor 7 interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55729|55729]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6VMQ6|Q6VMQ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATF7IP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATF7IP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613644|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of methylation-dependent chromatin silencing|
|regulation of methylation-dependent chromatin silencing|
|regulation of RNA polymerase II transcriptional preinitiation complex assembly|
|positive regulation of chromatin silencing|
|regulation of transcription initiation from RNA polymerase II promoter|
|regulation of DNA-templated transcription, initiation|
|regulation of chromatin silencing|
|DNA alkylation|
|DNA methylation|
|DNA methylation or demethylation|
|DNA modification|
|positive regulation of chromatin organization|
|regulation of gene silencing|
|positive regulation of chromosome organization|
|protein stabilization|
|regulation of chromatin organization|
|transcription factor complex|
|ATPase activity|
|transcription corepressor activity|
|macromolecule methylation|
|nuclear body|
|regulation of protein stability|
|methylation|
|regulation of chromosome organization|
|regulation of protein complex assembly|
|positive regulation of organelle organization|
|viral process|
|DNA metabolic process|
|symbiotic process|
|interspecies interaction between organisms|
|negative regulation of transcription by RNA polymerase II|
|regulation of cellular component biogenesis|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.49|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-2.36|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.23|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.09|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-2.02|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.01|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.84|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.84|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.83|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.83|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.83|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.81|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.78|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.72|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.7|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.72|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.74|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.74|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.79|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.05|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.22|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.26|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.38|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.67|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.83|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.85|
|[[:results:exp59|UMK57 1μM R01 exp59]]|3.18|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|3.24|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|6.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cbx3|CBX3]]|0.596|
|[[:human genes:s:setdb1|SETDB1]]|0.538|
|[[:human genes:m:mllt1|MLLT1]]|0.512|
|[[:human genes:i:id3|ID3]]|0.51|
|[[:human genes:t:thoc6|THOC6]]|0.506|
|[[:human genes:m:med23|MED23]]|0.503|
|[[:human genes:d:dhx29|DHX29]]|0.486|
|[[:human genes:d:dohh|DOHH]]|0.47|
|[[:human genes:c:ccdc101|CCDC101]]|0.468|
|[[:human genes:g:gnb1l|GNB1L]]|0.463|
|[[:human genes:m:mapk14|MAPK14]]|0.463|
|[[:human genes:b:bap1|BAP1]]|0.459|
|[[:human genes:n:nsd1|NSD1]]|0.457|
|[[:human genes:z:znf592|ZNF592]]|0.451|
|[[:human genes:m:maml1|MAML1]]|0.446|
|[[:human genes:t:trip12|TRIP12]]|0.445|
|[[:human genes:t:trim28|TRIM28]]|0.443|
|[[:human genes:r:rptor|RPTOR]]|0.443|
|[[:human genes:t:tti2|TTI2]]|0.442|
|[[:human genes:c:cbfb|CBFB]]|0.435|
|[[:human genes:a:arih1|ARIH1]]|0.433|
|[[:human genes:t:taf5l|TAF5L]]|0.432|
|[[:human genes:t:tada1|TADA1]]|0.425|
|[[:human genes:a:arl14ep|ARL14EP]]|0.424|
|[[:human genes:r:rnmt|RNMT]]|0.423|
|[[:human genes:b:brpf1|BRPF1]]|0.421|
|[[:human genes:d:ddx5|DDX5]]|0.419|
|[[:human genes:a:aars|AARS]]|0.418|
|[[:human genes:t:taf6l|TAF6L]]|0.417|
|[[:human genes:s:ssbp2|SSBP2]]|0.417|
|[[:human genes:t:tti1|TTI1]]|0.415|
|[[:human genes:t:tmem41b|TMEM41B]]|0.415|
|[[:human genes:h:hhex|HHEX]]|0.414|
|[[:human genes:o:otud5|OTUD5]]|0.413|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.413|
|[[:human genes:f:fbxo11|FBXO11]]|0.412|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.412|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.411|
|[[:human genes:t:tceb3|TCEB3]]|0.41|
|[[:human genes:d:dpagt1|DPAGT1]]|0.409|
|[[:human genes:d:dcaf5|DCAF5]]|0.406|
|[[:human genes:x:xpot|XPOT]]|0.406|
|[[:human genes:m:med16|MED16]]|0.405|
|[[:human genes:z:znf445|ZNF445]]|0.402|
|[[:human genes:s:sox7|SOX7]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6785
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATF7IP Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>