======= ATG5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATG5
  * **<color #00a2e8>Official Name</color>**: autophagy related 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9474|9474]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H1Y0|Q9H1Y0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATG5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATG5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604261|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. {ECO:0000250|UniProtKB:Q99J83, ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:20580051, ECO:0000269|PubMed:22170153, ECO:0000269|PubMed:26812546}. (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established (PubMed:19666601). {ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:19666601}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|APG5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative stranded viral RNA replication|
|negative regulation of histone H4-K16 acetylation|
|Atg12-Atg5-Atg16 complex|
|Atg8 ligase activity|
|protein lipidation involved in autophagosome assembly|
|cellular response to nitrosative stress|
|negative regulation of histone H4 acetylation|
|C-terminal protein lipidation|
|positive regulation of mucus secretion|
|modulation by symbiont of host autophagy|
|positive regulation by symbiont of host autophagy|
|aggrephagy|
|regulation of histone H4-K16 acetylation|
|response to nitrosative stress|
|regulation of mucus secretion|
|otolith development|
|negative thymic T cell selection|
|ventricular cardiac muscle cell development|
|negative T cell selection|
|cellular response to nitrogen starvation|
|viral RNA genome replication|
|regulation of histone H4 acetylation|
|mitochondria-associated endoplasmic reticulum membrane|
|cellular response to nitrogen levels|
|C-terminal protein amino acid modification|
|negative regulation of histone acetylation|
|phagophore assembly site membrane|
|regulation of cytokine secretion involved in immune response|
|ventricular cardiac muscle cell differentiation|
|negative regulation of peptidyl-lysine acetylation|
|thymic T cell selection|
|negative regulation of phagocytosis|
|negative regulation of protein acetylation|
|antigen processing and presentation of endogenous antigen|
|selective autophagy|
|modulation by symbiont of host cellular process|
|viral genome replication|
|vasodilation|
|blood vessel remodeling|
|mitochondrion disassembly|
|T cell selection|
|autophagy of mitochondrion|
|negative regulation of histone modification|
|modification by symbiont of host morphology or physiology|
|T cell differentiation in thymus|
|response to fungus|
|negative regulation of reactive oxygen species metabolic process|
|regulation of histone acetylation|
|positive regulation of blood vessel diameter|
|cardiac muscle cell development|
|negative regulation of chromatin organization|
|autophagosome assembly|
|regulation of peptidyl-lysine acetylation|
|organelle disassembly|
|autophagosome organization|
|cardiac cell development|
|autophagosome|
|regulation of protein acetylation|
|negative regulation of protein ubiquitination|
|phagocytic vesicle membrane|
|regulation of release of sequestered calcium ion into cytosol|
|regulation of cilium assembly|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of cytokine production involved in immune response|
|protein lipidation|
|heart contraction|
|cardiac muscle cell differentiation|
|lipoprotein biosynthetic process|
|regulation of phagocytosis|
|regulation of calcium ion transport into cytosol|
|heart process|
|tissue remodeling|
|axoneme|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|cardiocyte differentiation|
|lipoprotein metabolic process|
|positive regulation of autophagy|
|regulation of sequestering of calcium ion|
|vacuole organization|
|negative regulation of chromosome organization|
|T cell differentiation|
|striated muscle cell development|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|regulation of production of molecular mediator of immune response|
|regulation of histone modification|
|regulation of calcium ion transmembrane transport|
|muscle cell development|
|cellular response to starvation|
|modification of morphology or physiology of other organism|
|interaction with host|
|macroautophagy|
|cardiac muscle tissue development|
|vascular process in circulatory system|
|regulation of reactive oxygen species metabolic process|
|regulation of chromatin organization|
|response to starvation|
|inner ear development|
|regulation of protein ubiquitination|
|regulation of plasma membrane bounded cell projection assembly|
|striated muscle cell differentiation|
|viral life cycle|
|regulation of cell projection assembly|
|regulation of cytokine secretion|
|antigen processing and presentation|
|regulation of organelle assembly|
|ear development|
|regulation of protein modification by small protein conjugation or removal|
|cellular response to nutrient levels|
|T cell activation|
|lymphocyte differentiation|
|muscle cell differentiation|
|regulation of calcium ion transport|
|autophagy|
|process utilizing autophagic mechanism|
|cellular response to extracellular stimulus|
|striated muscle tissue development|
|muscle tissue development|
|leukocyte differentiation|
|regulation of autophagy|
|regulation of cation transmembrane transport|
|cellular response to external stimulus|
|regulation of chromosome organization|
|post-translational protein modification|
|positive regulation of cellular catabolic process|
|negative regulation of organelle organization|
|lymphocyte activation|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|cellular component disassembly|
|positive regulation of catabolic process|
|positive regulation of secretion|
|mitochondrion organization|
|regulation of protein secretion|
|regulation of immune effector process|
|muscle structure development|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of body fluid levels|
|response to nutrient levels|
|regulation of anatomical structure size|
|heart development|
|response to extracellular stimulus|
|sensory organ development|
|regulation of vesicle-mediated transport|
|hemopoiesis|
|regulation of transmembrane transport|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|immune system development|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|regulation of ion transport|
|viral process|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|organelle assembly|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|circulatory system development|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|apoptotic process|
|leukocyte activation|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell activation|
|cell death|
|negative regulation of protein metabolic process|
|regulation of immune response|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|organonitrogen compound biosynthetic process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|homeostatic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|cellular catabolic process|
|regulation of protein modification process|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.71|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17381
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATG5 Expression in NALM6 Cells: 4.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>