======= ATP1A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP1A1
  * **<color #00a2e8>Official Name</color>**: ATPase Na+/K+ transporting subunit alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=476|476]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05023|P05023]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP1A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP1A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182310|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hydrolase|
|Cation ATPase C|
|HAD|
|E1-E2 ATPase|
|Cation ATPase N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to glycoside|
|negative regulation of glucocorticoid metabolic process|
|negative regulation of glucocorticoid biosynthetic process|
|negative regulation of steroid hormone biosynthetic process|
|steroid hormone binding|
|regulation of glucocorticoid biosynthetic process|
|sodium ion binding|
|regulation of glucocorticoid metabolic process|
|membrane hyperpolarization|
|negative regulation of hormone biosynthetic process|
|regulation of steroid hormone biosynthetic process|
|sodium:potassium-exchanging ATPase activity|
|negative regulation of hormone metabolic process|
|potassium ion binding|
|sodium:potassium-exchanging ATPase complex|
|relaxation of cardiac muscle|
|cellular potassium ion homeostasis|
|sodium ion export across plasma membrane|
|positive regulation of striated muscle contraction|
|establishment or maintenance of transmembrane electrochemical gradient|
|cell communication by electrical coupling involved in cardiac conduction|
|cellular sodium ion homeostasis|
|membrane repolarization during action potential|
|membrane repolarization during cardiac muscle cell action potential|
|cardiac muscle cell membrane repolarization|
|cell communication by electrical coupling|
|ankyrin binding|
|relaxation of muscle|
|phosphatidylinositol 3-kinase binding|
|membrane repolarization|
|negative regulation of steroid biosynthetic process|
|negative regulation of heart contraction|
|negative regulation of steroid metabolic process|
|regulation of the force of heart contraction|
|regulation of hormone biosynthetic process|
|potassium ion homeostasis|
|negative regulation of blood circulation|
|sodium ion homeostasis|
|ADP binding|
|regulation of cardiac muscle cell contraction|
|regulation of hormone metabolic process|
|positive regulation of heart contraction|
|export across plasma membrane|
|cardiac muscle cell action potential involved in contraction|
|regulation of actin filament-based movement|
|cardiac muscle cell contraction|
|T-tubule|
|potassium ion import across plasma membrane|
|cell communication involved in cardiac conduction|
|positive regulation of muscle contraction|
|intercalated disc|
|phosphatase activity|
|negative regulation of lipid biosynthetic process|
|cardiac muscle cell action potential|
|extracellular vesicle|
|regulation of cardiac conduction|
|positive regulation of blood circulation|
|caveola|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|regulation of cardiac muscle contraction|
|cardiac muscle contraction|
|cellular response to mechanical stimulus|
|negative regulation of lipid metabolic process|
|regulation of sodium ion transport|
|heart contraction|
|regulation of steroid biosynthetic process|
|actin-mediated cell contraction|
|sodium ion transmembrane transport|
|regulation of striated muscle contraction|
|cardiac conduction|
|action potential|
|import across plasma membrane|
|sarcolemma|
|heart process|
|melanosome|
|chaperone binding|
|striated muscle contraction|
|cellular monovalent inorganic cation homeostasis|
|actin filament-based movement|
|regulation of steroid metabolic process|
|multicellular organismal signaling|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|sodium ion transport|
|potassium ion transmembrane transport|
|regulation of muscle contraction|
|potassium ion transport|
|regulation of blood pressure|
|regulation of lipid biosynthetic process|
|cellular response to steroid hormone stimulus|
|basolateral plasma membrane|
|response to mechanical stimulus|
|regulation of muscle system process|
|regulation of heart contraction|
|protein domain specific binding|
|muscle contraction|
|postsynaptic density|
|endosome|
|regulation of blood circulation|
|muscle system process|
|dephosphorylation|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|apical plasma membrane|
|response to steroid hormone|
|cellular response to external stimulus|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|blood circulation|
|regulation of lipid metabolic process|
|circulatory system process|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|protein kinase binding|
|cellular response to lipid|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|actin filament-based process|
|regulation of system process|
|protein-containing complex|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|import into cell|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|ion transmembrane transport|
|Golgi apparatus|
|regulation of cellular component movement|
|endoplasmic reticulum|
|response to drug|
|export from cell|
|chemical homeostasis|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|homeostatic process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.53|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.25|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.16|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.8|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-1.79|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.7|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.84|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.86|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.91|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.92|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.96|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.98|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.05|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.11|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.22|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.25|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.47|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.58|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.69|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.77|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.88|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.04|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|3.05|
|[[:results:exp59|UMK57 1μM R01 exp59]]|3.05|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|3.41|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|4.19|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|4.77|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|6.06|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|6.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tmem161b|TMEM161B]]|0.772|
|[[:human genes:p:pigo|PIGO]]|0.635|
|[[:human genes:a:atp1b3|ATP1B3]]|0.613|
|[[:human genes:p:pigf|PIGF]]|0.579|
|[[:human genes:a:atat1|ATAT1]]|0.527|
|[[:human genes:n:ndrg3|NDRG3]]|0.504|
|[[:human genes:a:ahcyl1|AHCYL1]]|0.459|
|[[:human genes:t:tmx2|TMX2]]|0.424|
|[[:human genes:s:samhd1|SAMHD1]]|0.408|
|[[:human genes:e:ehmt2|EHMT2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 602/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|25/28|
|bone|16/26|
|breast|31/33|
|central nervous system|33/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/13|
|fibroblast|0/1|
|gastric|14/16|
|kidney|18/21|
|liver|16/20|
|lung|59/75|
|lymphocyte|15/16|
|ovary|22/26|
|pancreas|24/24|
|peripheral nervous system|4/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|21/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|21/22|
|urinary tract|25/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1470
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP1A1 Expression in NALM6 Cells: 9.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>