======= ATP1A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP1A2
  * **<color #00a2e8>Official Name</color>**: ATPase Na+/K+ transporting subunit alpha 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=477|477]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50993|P50993]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP1A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP1A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182340|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cation ATPase C|
|HAD|
|E1-E2 ATPase|
|Cation ATPase N|
|Hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of calcium:sodium antiporter activity|
|regulation of glutamate uptake involved in transmission of nerve impulse|
|regulation of amino acid uptake involved in synaptic transmission|
|regulation of calcium:sodium antiporter activity|
|response to glycoside|
|regulation of L-glutamate import across plasma membrane|
|steroid hormone binding|
|sodium ion binding|
|negative regulation of striated muscle contraction|
|regulation of amino acid import across plasma membrane|
|regulation of amino acid transmembrane transport|
|sodium:potassium-exchanging ATPase activity|
|potassium ion binding|
|negative regulation of sodium ion transmembrane transporter activity|
|sodium:potassium-exchanging ATPase complex|
|negative regulation of cytosolic calcium ion concentration|
|relaxation of cardiac muscle|
|cellular potassium ion homeostasis|
|regulation of respiratory gaseous exchange by nervous system process|
|negative regulation of sodium ion transmembrane transport|
|sodium ion export across plasma membrane|
|establishment or maintenance of transmembrane electrochemical gradient|
|regulation of respiratory system process|
|cell communication by electrical coupling involved in cardiac conduction|
|cellular sodium ion homeostasis|
|membrane depolarization during cardiac muscle cell action potential|
|negative regulation of sodium ion transport|
|cell communication by electrical coupling|
|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|
|regulation of neurotransmitter uptake|
|relaxation of muscle|
|membrane repolarization|
|regulation of respiratory gaseous exchange|
|negative regulation of muscle contraction|
|negative regulation of heart contraction|
|regulation of cardiac muscle contraction by calcium ion signaling|
|regulation of the force of heart contraction|
|regulation of anion transmembrane transport|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|neurotransmitter uptake|
|potassium ion homeostasis|
|membrane depolarization during action potential|
|regulation of amino acid transport|
|negative regulation of blood circulation|
|sodium ion homeostasis|
|negative regulation of calcium ion transmembrane transporter activity|
|regulation of cardiac muscle cell contraction|
|negative regulation of calcium ion transmembrane transport|
|export across plasma membrane|
|regulation of actin filament-based movement|
|T-tubule|
|potassium ion import across plasma membrane|
|cell communication involved in cardiac conduction|
|intercalated disc|
|visual learning|
|cardiac muscle cell action potential|
|response to nicotine|
|membrane depolarization|
|regulation of sodium ion transmembrane transporter activity|
|visual behavior|
|extracellular vesicle|
|drug binding|
|regulation of vasoconstriction|
|regulation of organic acid transport|
|negative regulation of calcium ion transport|
|regulation of smooth muscle contraction|
|regulation of sodium ion transmembrane transport|
|regulation of cardiac conduction|
|regulation of synaptic transmission, glutamatergic|
|negative regulation of ion transmembrane transporter activity|
|caveola|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|regulation of cardiac muscle contraction|
|adult locomotory behavior|
|associative learning|
|regulation of release of sequestered calcium ion into cytosol|
|cardiac muscle contraction|
|negative regulation of transporter activity|
|cellular response to mechanical stimulus|
|negative regulation of cation transmembrane transport|
|regulation of sodium ion transport|
|heart contraction|
|regulation of calcium ion transmembrane transporter activity|
|sodium ion transmembrane transport|
|regulation of striated muscle contraction|
|cardiac conduction|
|regulation of amine transport|
|action potential|
|negative regulation of ion transmembrane transport|
|regulation of anion transport|
|import across plasma membrane|
|regulation of calcium ion transport into cytosol|
|regulation of response to drug|
|heart process|
|chaperone binding|
|striated muscle contraction|
|cellular monovalent inorganic cation homeostasis|
|negative regulation of transmembrane transport|
|regulation of sequestering of calcium ion|
|multicellular organismal signaling|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|regulation of neurotransmitter transport|
|adult behavior|
|calcium-mediated signaling|
|learning|
|regulation of calcium ion transmembrane transport|
|negative regulation of ion transport|
|dendritic spine|
|sodium ion transport|
|potassium ion transmembrane transport|
|regulation of muscle contraction|
|potassium ion transport|
|vascular process in circulatory system|
|neurotransmitter transport|
|regulation of blood pressure|
|cellular response to steroid hormone stimulus|
|locomotory behavior|
|ATP metabolic process|
|response to mechanical stimulus|
|ATPase activity|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of calcium ion transport|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|endosome|
|regulation of transporter activity|
|regulation of blood circulation|
|cognition|
|muscle system process|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of cytosolic calcium ion concentration|
|response to steroid hormone|
|regulation of cation transmembrane transport|
|cellular response to external stimulus|
|second-messenger-mediated signaling|
|regulation of neurotransmitter levels|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|response to toxic substance|
|regulation of anatomical structure size|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|behavior|
|regulation of system process|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|import into cell|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|ion transmembrane transport|
|regulation of cellular component movement|
|response to drug|
|export from cell|
|chemical homeostasis|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|transmembrane transport|
|locomotion|
|ion transport|
|nervous system process|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|homeostatic process|
|intracellular signal transduction|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.447|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2819
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP1A2 Expression in NALM6 Cells: 2.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>