======= ATP1A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP1A3
  * **<color #00a2e8>Official Name</color>**: ATPase Na+/K+ transporting subunit alpha 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=478|478]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13637|P13637]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP1A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP1A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182350|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hydrolase|
|E1-E2 ATPase|
|Cation ATPase N|
|HAD|
|Cation ATPase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ion antiporter activity involved in regulation of presynaptic membrane potential|
|response to glycoside|
|steroid hormone binding|
|regulation of resting membrane potential|
|neuron projection maintenance|
|sodium:potassium-exchanging ATPase activity|
|sodium:potassium-exchanging ATPase complex|
|cellular potassium ion homeostasis|
|sodium ion export across plasma membrane|
|establishment or maintenance of transmembrane electrochemical gradient|
|cell communication by electrical coupling involved in cardiac conduction|
|cellular sodium ion homeostasis|
|cell communication by electrical coupling|
|neuronal cell body membrane|
|potassium ion homeostasis|
|sodium ion homeostasis|
|cellular response to amyloid-beta|
|export across plasma membrane|
|neuron projection organization|
|potassium ion import across plasma membrane|
|cell communication involved in cardiac conduction|
|response to amyloid-beta|
|extracellular vesicle|
|regulation of cardiac conduction|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|amyloid-beta binding|
|sodium ion transmembrane transport|
|cardiac conduction|
|import across plasma membrane|
|chaperone binding|
|cellular monovalent inorganic cation homeostasis|
|multicellular organismal signaling|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|sodium ion transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|cellular response to steroid hormone stimulus|
|regulation of heart contraction|
|synapse|
|regulation of blood circulation|
|axon|
|cellular response to peptide|
|response to steroid hormone|
|neuronal cell body|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|response to peptide|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|import into cell|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|ion transmembrane transport|
|Golgi apparatus|
|response to organonitrogen compound|
|endoplasmic reticulum|
|export from cell|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|homeostatic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.72|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.9|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.93|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:disp2|DISP2]]|0.541|
|[[:human genes:n:numa1|NUMA1]]|0.495|
|[[:human genes:c:copg1|COPG1]]|0.493|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.48|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.468|
|[[:human genes:t:tceb3c|TCEB3C]]|0.456|
|[[:human genes:r:ranbp2|RANBP2]]|0.455|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.454|
|[[:human genes:u:utp3|UTP3]]|0.449|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.446|
|[[:human genes:p:polr2d|POLR2D]]|0.443|
|[[:human genes:m:myt1l|MYT1L]]|0.438|
|[[:human genes:p:polr2j3|POLR2J3]]|0.438|
|[[:human genes:c:copa|COPA]]|0.431|
|[[:human genes:v:vps54|VPS54]]|0.431|
|[[:human genes:k:krt78|KRT78]]|0.429|
|[[:human genes:k:klhl1|KLHL1]]|0.424|
|[[:human genes:p:polr2f|POLR2F]]|0.421|
|[[:human genes:c:c14orf93|C14orf93]]|0.419|
|[[:human genes:c:chd4|CHD4]]|0.418|
|[[:human genes:a:aqr|AQR]]|0.418|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.417|
|[[:human genes:a:ankle1|ANKLE1]]|0.417|
|[[:human genes:n:napa|NAPA]]|0.414|
|[[:human genes:f:fam160a1|FAM160A1]]|0.413|
|[[:human genes:c:cdc7|CDC7]]|0.412|
|[[:human genes:k:kif3c|KIF3C]]|0.408|
|[[:human genes:h:hk1|HK1]]|0.408|
|[[:human genes:p:psmd3|PSMD3]]|0.406|
|[[:human genes:f:fcn2|FCN2]]|0.406|
|[[:human genes:r:rpl30|RPL30]]|0.404|
|[[:human genes:f:fam25b|FAM25B]]|0.403|
|[[:human genes:t:twistnb|TWISTNB]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2060
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP1A3 Expression in NALM6 Cells: 8.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>