======= ATP2A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP2A2
  * **<color #00a2e8>Official Name</color>**: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=488|488]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16615|P16615]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP2A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP2A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108740|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (PubMed:16402920). Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11- induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:16402920}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hydrolase|
|E1-E2 ATPase|
|Cation ATPase N|
|Cation ATPase C|
|HAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium ion transport from cytosol to endoplasmic reticulum|
|apical ectoplasmic specialization|
|calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential|
|lutropin-choriogonadotropic hormone receptor binding|
|plasma membrane bounded cell projection|
|positive regulation of endoplasmic reticulum calcium ion concentration|
|calcium ion import into sarcoplasmic reticulum|
|ribbon synapse|
|cytosol to endoplasmic reticulum transport|
|regulation of calcium ion-dependent exocytosis of neurotransmitter|
|regulation of cardiac muscle cell membrane potential|
|regulation of cardiac muscle cell action potential involved in regulation of contraction|
|T-tubule organization|
|transition between fast and slow fiber|
|platelet dense tubular network membrane|
|calcium transmembrane transporter activity, phosphorylative mechanism|
|relaxation of cardiac muscle|
|proton-exporting ATPase activity, phosphorylative mechanism|
|muscle hypertrophy in response to stress|
|cardiac muscle adaptation|
|cardiac muscle hypertrophy in response to stress|
|sarcoplasmic reticulum calcium ion transport|
|regulation of skeletal muscle adaptation|
|S100 protein binding|
|relaxation of muscle|
|endoplasmic reticulum calcium ion homeostasis|
|positive regulation of heart rate|
|negative regulation of heart contraction|
|regulation of cardiac muscle contraction by calcium ion signaling|
|striated muscle adaptation|
|regulation of the force of heart contraction|
|regulation of cardiac muscle cell action potential|
|vesicle membrane|
|cardiac muscle hypertrophy|
|skeletal muscle contraction|
|striated muscle hypertrophy|
|sarcoplasmic reticulum membrane|
|muscle hypertrophy|
|muscle adaptation|
|negative regulation of blood circulation|
|ER-nucleus signaling pathway|
|regulation of cardiac muscle cell contraction|
|positive regulation of heart contraction|
|regulation of actin filament-based movement|
|calcium ion import|
|musculoskeletal movement|
|multicellular organismal movement|
|regulation of calcium ion-dependent exocytosis|
|sarcoplasmic reticulum|
|regulation of action potential|
|extrinsic component of cytoplasmic side of plasma membrane|
|regulation of cardiac conduction|
|cellular response to heat|
|positive regulation of blood circulation|
|regulation of cardiac muscle contraction|
|regulation of synaptic vesicle exocytosis|
|regulation of muscle adaptation|
|cytosolic calcium ion transport|
|regulation of striated muscle contraction|
|plasma membrane organization|
|regulation of heart rate|
|regulation of neurotransmitter secretion|
|striated muscle contraction|
|response to heat|
|regulation of synaptic vesicle cycle|
|proton transmembrane transport|
|regulation of neurotransmitter transport|
|calcium-mediated signaling|
|muscle cell development|
|regulation of muscle contraction|
|regulation of regulated secretory pathway|
|response to temperature stimulus|
|calcium ion transmembrane transport|
|regulation of exocytosis|
|regulation of muscle system process|
|cellular response to oxidative stress|
|regulation of heart contraction|
|muscle cell differentiation|
|calcium ion transport|
|muscle contraction|
|response to endoplasmic reticulum stress|
|regulation of blood circulation|
|divalent metal ion transport|
|muscle system process|
|divalent inorganic cation transport|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|second-messenger-mediated signaling|
|enzyme binding|
|regulation of neurotransmitter levels|
|response to oxidative stress|
|regulation of actin filament-based process|
|monovalent inorganic cation transport|
|epidermis development|
|endomembrane system organization|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|muscle structure development|
|divalent inorganic cation homeostasis|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of system process|
|protein-containing complex|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|response to bacterium|
|perinuclear region of cytoplasm|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|membrane organization|
|response to lipid|
|cellular homeostasis|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|regulation of cellular component movement|
|endoplasmic reticulum|
|chemical homeostasis|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|ion transport|
|integral component of plasma membrane|
|ATP binding|
|intracellular transport|
|response to oxygen-containing compound|
|homeostatic process|
|cell development|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|tissue development|
|establishment of localization in cell|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.83|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.52|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.51|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.25|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-2.22|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.19|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-2.11|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.11|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.11|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-2.1|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-2.08|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.05|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.01|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.01|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.93|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.87|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.85|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.82|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.75|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.73|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.7|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.71|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.75|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.79|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.85|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.92|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.03|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.11|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.13|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.14|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.41|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.54|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.534|
|[[:human genes:s:srp14|SRP14]]|0.532|
|[[:human genes:d:dpagt1|DPAGT1]]|0.525|
|[[:human genes:p:pmm2|PMM2]]|0.522|
|[[:human genes:d:dohh|DOHH]]|0.507|
|[[:human genes:r:romo1|ROMO1]]|0.502|
|[[:human genes:a:atxn10|ATXN10]]|0.502|
|[[:human genes:s:srd5a3|SRD5A3]]|0.49|
|[[:human genes:g:gfpt1|GFPT1]]|0.488|
|[[:human genes:d:dolk|DOLK]]|0.486|
|[[:human genes:c:cept1|CEPT1]]|0.484|
|[[:human genes:u:uap1|UAP1]]|0.483|
|[[:human genes:t:triap1|TRIAP1]]|0.479|
|[[:human genes:a:alg1|ALG1]]|0.479|
|[[:human genes:r:rnmt|RNMT]]|0.466|
|[[:human genes:k:kdsr|KDSR]]|0.466|
|[[:human genes:a:apaf1|APAF1]]|0.463|
|[[:human genes:d:dhrsx|DHRSX]]|0.463|
|[[:human genes:b:bap1|BAP1]]|0.461|
|[[:human genes:c:crls1|CRLS1]]|0.459|
|[[:human genes:p:pdpk1|PDPK1]]|0.456|
|[[:human genes:v:vmp1|VMP1]]|0.455|
|[[:human genes:f:flvcr1|FLVCR1]]|0.455|
|[[:human genes:g:gmppb|GMPPB]]|0.453|
|[[:human genes:p:ppa2|PPA2]]|0.45|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.444|
|[[:human genes:b:bak1|BAK1]]|0.443|
|[[:human genes:s:sec61g|SEC61G]]|0.443|
|[[:human genes:a:alg2|ALG2]]|0.438|
|[[:human genes:c:cbfb|CBFB]]|0.438|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.435|
|[[:human genes:a:alg5|ALG5]]|0.432|
|[[:human genes:m:mbtps2|MBTPS2]]|0.429|
|[[:human genes:h:hspd1|HSPD1]]|0.428|
|[[:human genes:u:ube2g2|UBE2G2]]|0.426|
|[[:human genes:s:sec63|SEC63]]|0.425|
|[[:human genes:s:sec62|SEC62]]|0.423|
|[[:human genes:r:rptor|RPTOR]]|0.423|
|[[:human genes:m:mbtps1|MBTPS1]]|0.422|
|[[:human genes:r:rpn1|RPN1]]|0.415|
|[[:human genes:e:eny2|ENY2]]|0.414|
|[[:human genes:t:timm13|TIMM13]]|0.413|
|[[:human genes:p:ppcs|PPCS]]|0.413|
|[[:human genes:p:pisd|PISD]]|0.413|
|[[:human genes:a:alg6|ALG6]]|0.412|
|[[:human genes:t:trmt61a|TRMT61A]]|0.412|
|[[:human genes:t:trmt10a|TRMT10A]]|0.411|
|[[:human genes:h:hccs|HCCS]]|0.411|
|[[:human genes:t:taz|TAZ]]|0.41|
|[[:human genes:t:tsen54|TSEN54]]|0.409|
|[[:human genes:p:plaa|PLAA]]|0.409|
|[[:human genes:r:rtcb|RTCB]]|0.407|
|[[:human genes:m:med16|MED16]]|0.407|
|[[:human genes:d:dpm3|DPM3]]|0.406|
|[[:human genes:d:dad1|DAD1]]|0.406|
|[[:human genes:d:dnajc3|DNAJC3]]|0.404|
|[[:human genes:o:opa1|OPA1]]|0.404|
|[[:human genes:c:chka|CHKA]]|0.404|
|[[:human genes:p:pik3r4|PIK3R4]]|0.401|
|[[:human genes:n:nsd1|NSD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 720/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|26/28|
|bone|26/26|
|breast|30/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|19/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 68
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP2A2 Expression in NALM6 Cells: 9.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>