======= ATP5I =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP5ME
  * **<color #00a2e8>Official Name</color>**: ATP synthase membrane subunit e
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=521|521]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56385|P56385]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP5I&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP5I|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601519|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt E|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|
|proton transmembrane transporter activity|
|mitochondrial proton-transporting ATP synthase complex|
|mitochondrial ATP synthesis coupled proton transport|
|energy coupled proton transport, down electrochemical gradient|
|ATP synthesis coupled proton transport|
|cristae formation|
|ATP biosynthetic process|
|inner mitochondrial membrane organization|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|purine ribonucleoside triphosphate metabolic process|
|transmembrane transporter activity|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|mitochondrial transmembrane transport|
|nucleoside triphosphate metabolic process|
|oxidative phosphorylation|
|mitochondrial membrane organization|
|proton transmembrane transport|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|mitochondrial transport|
|ATPase activity|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|protein-containing complex binding|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|carbohydrate derivative biosynthetic process|
|inorganic ion transmembrane transport|
|cation transport|
|membrane organization|
|organophosphate metabolic process|
|ion transmembrane transport|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.71|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.73|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.75|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.8|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.82|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.89|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.92|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.96|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.13|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.15|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.32|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.37|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp5b|ATP5B]]|0.586|
|[[:human genes:a:atp5d|ATP5D]]|0.572|
|[[:human genes:a:atp5j|ATP5J]]|0.559|
|[[:human genes:a:atp5c1|ATP5C1]]|0.543|
|[[:human genes:a:atp5o|ATP5O]]|0.539|
|[[:human genes:a:atp5a1|ATP5A1]]|0.537|
|[[:human genes:a:atp5f1|ATP5F1]]|0.516|
|[[:human genes:a:atp5l|ATP5L]]|0.516|
|[[:human genes:u:ube2g2|UBE2G2]]|0.478|
|[[:human genes:h:hccs|HCCS]]|0.473|
|[[:human genes:e:eny2|ENY2]]|0.471|
|[[:human genes:f:faf2|FAF2]]|0.471|
|[[:human genes:c:cycs|CYCS]]|0.468|
|[[:human genes:c:casp9|CASP9]]|0.467|
|[[:human genes:p:plaa|PLAA]]|0.465|
|[[:human genes:g:gfpt1|GFPT1]]|0.456|
|[[:human genes:o:opa1|OPA1]]|0.449|
|[[:human genes:t:triap1|TRIAP1]]|0.446|
|[[:human genes:d:dohh|DOHH]]|0.445|
|[[:human genes:a:apaf1|APAF1]]|0.437|
|[[:human genes:k:kdsr|KDSR]]|0.43|
|[[:human genes:h:hspd1|HSPD1]]|0.427|
|[[:human genes:s:serf2|SERF2]]|0.406|
|[[:human genes:g:gmppb|GMPPB]]|0.404|
|[[:human genes:a:atp5h|ATP5H]]|0.404|
|[[:human genes:c:cbfb|CBFB]]|0.404|
|[[:human genes:t:thg1l|THG1L]]|0.404|
|[[:human genes:u:uap1|UAP1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 185/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|4/28|
|bone|2/26|
|breast|7/33|
|central nervous system|9/56|
|cervix|2/4|
|colorectal|5/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|6/21|
|liver|12/20|
|lung|23/75|
|lymphocyte|2/16|
|ovary|5/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|7/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2179
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP5I Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>