======= ATP6AP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP6AP1
  * **<color #00a2e8>Official Name</color>**: ATPase H+ transporting accessory protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=537|537]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15904|Q15904]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP6AP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP6AP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300197|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:28296633, ECO:0000305|PubMed:27231034}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt S1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of osteoclast development|
|plasma membrane proton-transporting V-type ATPase complex|
|proton-transporting two-sector ATPase complex|
|proton-transporting V-type ATPase, V1 domain|
|positive regulation of bone development|
|regulation of osteoclast development|
|cellular response to increased oxygen levels|
|positive regulation of bone resorption|
|positive regulation of bone remodeling|
|proton-transporting ATP synthase activity, rotational mechanism|
|proton-transporting ATPase activity, rotational mechanism|
|regulation of bone development|
|positive regulation of osteoclast differentiation|
|response to increased oxygen levels|
|positive regulation of tissue remodeling|
|transferrin transport|
|transporter activity|
|regulation of bone resorption|
|pH reduction|
|regulation of bone remodeling|
|positive regulation of myeloid leukocyte differentiation|
|positive regulation of osteoblast differentiation|
|cellular iron ion homeostasis|
|regulation of osteoclast differentiation|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|iron ion transport|
|regulation of tissue remodeling|
|iron ion homeostasis|
|positive regulation of ossification|
|insulin receptor signaling pathway|
|positive regulation of exocytosis|
|regulation of cellular pH|
|positive regulation of myeloid cell differentiation|
|regulation of pH|
|cellular transition metal ion homeostasis|
|cellular monovalent inorganic cation homeostasis|
|regulation of osteoblast differentiation|
|regulation of myeloid leukocyte differentiation|
|transition metal ion transport|
|transition metal ion homeostasis|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|positive regulation of leukocyte differentiation|
|Rab GTPase binding|
|cellular response to insulin stimulus|
|positive regulation of hemopoiesis|
|regulation of ossification|
|positive regulation of ERK1 and ERK2 cascade|
|endosome membrane|
|cellular response to oxygen levels|
|regulation of exocytosis|
|regulation of myeloid cell differentiation|
|response to insulin|
|cellular response to peptide hormone stimulus|
|regulation of leukocyte differentiation|
|regulation of ERK1 and ERK2 cascade|
|cellular response to peptide|
|establishment of organelle localization|
|response to oxygen levels|
|response to peptide hormone|
|monovalent inorganic cation transport|
|positive regulation of secretion by cell|
|positive regulation of secretion|
|regulation of hemopoiesis|
|response to peptide|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|organelle localization|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|cellular homeostasis|
|response to hormone|
|regulation of cell development|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|positive regulation of cell differentiation|
|positive regulation of transport|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|transmembrane transport|
|positive regulation of developmental process|
|ion transport|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-3.24|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-3.17|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-2.97|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.78|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.77|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.52|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.48|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.31|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.17|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.15|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.13|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.09|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.09|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.05|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-2.03|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.99|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.94|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.91|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.9|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.9|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.9|
|[[:results:exp539|42°C R08 exp539]]|-1.88|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.82|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.79|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.78|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.73|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.72|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.71|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.75|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.77|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.78|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.81|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.83|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.85|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.93|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.98|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.99|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.99|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|2.02|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.08|
|[[:results:exp331|A-769662 20μM R07 exp331]]|2.09|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.09|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.19|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.26|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|2.67|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.528|
|[[:human genes:t:tceb3c|TCEB3C]]|0.503|
|[[:human genes:p:psma6|PSMA6]]|0.496|
|[[:human genes:s:supt5h|SUPT5H]]|0.491|
|[[:human genes:p:psmb4|PSMB4]]|0.486|
|[[:human genes:c:ccna2|CCNA2]]|0.485|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.483|
|[[:human genes:n:npipb5|NPIPB5]]|0.479|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.473|
|[[:human genes:t:tsg101|TSG101]]|0.473|
|[[:human genes:t:ticrr|TICRR]]|0.473|
|[[:human genes:r:rps2|RPS2]]|0.473|
|[[:human genes:c:chd4|CHD4]]|0.472|
|[[:human genes:c:cdca3|CDCA3]]|0.469|
|[[:human genes:o:or10g3|OR10G3]]|0.468|
|[[:human genes:a:aqr|AQR]]|0.464|
|[[:human genes:c:copg1|COPG1]]|0.459|
|[[:human genes:v:vps28|VPS28]]|0.456|
|[[:human genes:t:tyms|TYMS]]|0.455|
|[[:human genes:c:cdc73|CDC73]]|0.454|
|[[:human genes:s:slc6a17|SLC6A17]]|0.451|
|[[:human genes:c:crnkl1|CRNKL1]]|0.443|
|[[:human genes:n:nupl1|NUPL1]]|0.44|
|[[:human genes:a:aamp|AAMP]]|0.436|
|[[:human genes:c:cactin|CACTIN]]|0.433|
|[[:human genes:p:psmb3|PSMB3]]|0.433|
|[[:human genes:p:psmb2|PSMB2]]|0.43|
|[[:human genes:p:psmd2|PSMD2]]|0.429|
|[[:human genes:d:dtl|DTL]]|0.428|
|[[:human genes:n:ndc80|NDC80]]|0.427|
|[[:human genes:r:rbbp5|RBBP5]]|0.426|
|[[:human genes:z:znf830|ZNF830]]|0.426|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.424|
|[[:human genes:c:cbwd3|CBWD3]]|0.424|
|[[:human genes:r:rpl35|RPL35]]|0.423|
|[[:human genes:t:twistnb|TWISTNB]]|0.423|
|[[:human genes:p:prim1|PRIM1]]|0.419|
|[[:human genes:c:c14orf93|C14orf93]]|0.418|
|[[:human genes:k:krt78|KRT78]]|0.418|
|[[:human genes:p:pola2|POLA2]]|0.418|
|[[:human genes:u:utp3|UTP3]]|0.418|
|[[:human genes:t:tfip11|TFIP11]]|0.418|
|[[:human genes:p:psma7|PSMA7]]|0.417|
|[[:human genes:p:psmc5|PSMC5]]|0.416|
|[[:human genes:g:golga8o|GOLGA8O]]|0.416|
|[[:human genes:c:col2a1|COL2A1]]|0.416|
|[[:human genes:c:cep192|CEP192]]|0.416|
|[[:human genes:p:polr2d|POLR2D]]|0.415|
|[[:human genes:c:chaf1a|CHAF1A]]|0.414|
|[[:human genes:u:utp20|UTP20]]|0.414|
|[[:human genes:b:bysl|BYSL]]|0.414|
|[[:human genes:t:tuba8|TUBA8]]|0.413|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.413|
|[[:human genes:c:copb1|COPB1]]|0.41|
|[[:human genes:i:ik|IK]]|0.408|
|[[:human genes:t:timeless|TIMELESS]]|0.408|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.407|
|[[:human genes:n:nol10|NOL10]]|0.407|
|[[:human genes:h:hinfp|HINFP]]|0.406|
|[[:human genes:l:lrr1|LRR1]]|0.406|
|[[:human genes:c:cbwd5|CBWD5]]|0.404|
|[[:human genes:p:psmd3|PSMD3]]|0.403|
|[[:human genes:c:cbwd6|CBWD6]]|0.403|
|[[:human genes:l:loxl1|LOXL1]]|0.402|
|[[:human genes:k:kctd17|KCTD17]]|0.401|
|[[:human genes:e:eif4a3|EIF4A3]]|0.401|
|[[:human genes:p:polr2f|POLR2F]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 642/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|27/28|
|blood|26/26|
|bone|22/26|
|breast|26/30|
|central nervous system|43/49|
|cervix|4/4|
|colorectal|16/17|
|esophagus|11/11|
|fibroblast|1/1|
|gastric|12/14|
|kidney|15/18|
|liver|19/19|
|lung|66/72|
|lymphocyte|16/16|
|ovary|22/25|
|pancreas|22/22|
|peripheral nervous system|14/15|
|plasma cell|12/12|
|prostate|1/1|
|skin|14/20|
|soft tissue|9/9|
|thyroid|1/2|
|upper aerodigestive|21/22|
|urinary tract|27/28|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 378
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP6AP1 Expression in NALM6 Cells: 7.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>