======= ATP6AP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP6AP2
  * **<color #00a2e8>Official Name</color>**: ATPase H+ transporting accessory protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10159|10159]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75787|O75787]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP6AP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP6AP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300556|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). {ECO:0000269|PubMed:12045255}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Renin r|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eye pigmentation|
|positive regulation of transforming growth factor beta1 production|
|regulation of transforming growth factor beta1 production|
|rostrocaudal neural tube patterning|
|regulation of angiotensin levels in blood|
|angiotensin maturation|
|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|
|positive regulation of transforming growth factor beta production|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|peptide hormone processing|
|neural tube patterning|
|regulation of transforming growth factor beta production|
|regulation of systemic arterial blood pressure by hormone|
|head morphogenesis|
|developmental pigmentation|
|body morphogenesis|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|ficolin-1-rich granule membrane|
|cell body|
|tertiary granule membrane|
|pigmentation|
|regulation of systemic arterial blood pressure|
|protein processing|
|neural tube development|
|positive regulation of Wnt signaling pathway|
|regulation of blood pressure|
|hormone metabolic process|
|signaling receptor activity|
|anterior/posterior pattern specification|
|protein maturation|
|apical plasma membrane|
|neuron projection|
|regionalization|
|regulation of Wnt signaling pathway|
|blood circulation|
|external side of plasma membrane|
|circulatory system process|
|pattern specification process|
|positive regulation of cytokine production|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|peptide metabolic process|
|regulation of hormone levels|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of cytokine production|
|regulated exocytosis|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|head development|
|cellular amide metabolic process|
|exocytosis|
|tube development|
|leukocyte activation|
|embryo development|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|epithelium development|
|secretion|
|proteolysis|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|vesicle-mediated transport|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.65|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.04|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.92|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.92|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.89|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.83|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.8|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.72|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.77|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.83|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.88|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.95|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.1|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|2.17|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.26|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.27|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:ticrr|TICRR]]|0.543|
|[[:human genes:o:osbp|OSBP]]|0.504|
|[[:human genes:p:polr2j3|POLR2J3]]|0.483|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.461|
|[[:human genes:p:pigs|PIGS]]|0.459|
|[[:human genes:r:rpl34|RPL34]]|0.437|
|[[:human genes:i:ik|IK]]|0.435|
|[[:human genes:t:tceb3c|TCEB3C]]|0.431|
|[[:human genes:c:cdca3|CDCA3]]|0.426|
|[[:human genes:a:ankle2|ANKLE2]]|0.425|
|[[:human genes:t:tyms|TYMS]]|0.425|
|[[:human genes:n:nol10|NOL10]]|0.424|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.42|
|[[:human genes:n:nupl1|NUPL1]]|0.42|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.419|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.418|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.417|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.417|
|[[:human genes:p:prpf19|PRPF19]]|0.416|
|[[:human genes:c:chd4|CHD4]]|0.412|
|[[:human genes:n:nbpf10|NBPF10]]|0.412|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.41|
|[[:human genes:p:psma6|PSMA6]]|0.408|
|[[:human genes:c:chaf1a|CHAF1A]]|0.408|
|[[:human genes:z:znf830|ZNF830]]|0.407|
|[[:human genes:p:pwp2|PWP2]]|0.401|
|[[:human genes:p:prim1|PRIM1]]|0.4|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.4|
|[[:human genes:c:cbwd3|CBWD3]]|0.4|
|[[:human genes:m:med14|MED14]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 611/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|25/28|
|blood|26/26|
|bone|22/26|
|breast|25/30|
|central nervous system|39/49|
|cervix|3/4|
|colorectal|17/17|
|esophagus|10/11|
|fibroblast|1/1|
|gastric|12/14|
|kidney|16/18|
|liver|16/19|
|lung|61/72|
|lymphocyte|15/16|
|ovary|20/25|
|pancreas|21/22|
|peripheral nervous system|15/15|
|plasma cell|12/12|
|prostate|1/1|
|skin|13/20|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|21/22|
|urinary tract|26/28|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 530
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP6AP2 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>