======= ATP6V0A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP6V0A1
  * **<color #00a2e8>Official Name</color>**: ATPase H+ transporting V0 subunit a1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=535|535]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q93050|Q93050]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP6V0A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP6V0A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/192130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V ATPase I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vacuolar proton-transporting V-type ATPase, V0 domain|
|vacuolar proton-transporting V-type ATPase complex|
|vacuolar acidification|
|proton-transporting ATPase activity, rotational mechanism|
|phagosome acidification|
|transferrin transport|
|toxin transport|
|phagosome maturation|
|intracellular pH reduction|
|pH reduction|
|ficolin-1-rich granule membrane|
|iron ion transport|
|phagocytic vesicle membrane|
|ATPase binding|
|regulation of intracellular pH|
|insulin receptor signaling pathway|
|regulation of cellular pH|
|secretory granule membrane|
|regulation of pH|
|melanosome|
|cellular monovalent inorganic cation homeostasis|
|transition metal ion transport|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|cellular response to insulin stimulus|
|regulation of macroautophagy|
|endosome membrane|
|response to insulin|
|cellular response to peptide hormone stimulus|
|lysosomal membrane|
|cellular response to peptide|
|regulation of autophagy|
|response to peptide hormone|
|monovalent inorganic cation transport|
|nuclear speck|
|response to peptide|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|inorganic cation transmembrane transport|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|leukocyte mediated immunity|
|ion homeostasis|
|exocytosis|
|cation transport|
|regulation of cellular catabolic process|
|cellular homeostasis|
|response to hormone|
|leukocyte activation|
|ion transmembrane transport|
|Golgi apparatus|
|regulation of catabolic process|
|response to organonitrogen compound|
|secretion by cell|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|chemical homeostasis|
|secretion|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-3.02|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-2.03|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.98|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.71|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13615
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP6V0A1 Expression in NALM6 Cells: 2.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>