======= ATP6V0C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP6V0C
  * **<color #00a2e8>Official Name</color>**: ATPase H+ transporting V0 subunit c
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=527|527]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P27449|P27449]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP6V0C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP6V0C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108745|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proton-transporting V-type ATPase, V0 domain|
|proton-transporting ATP synthase activity, rotational mechanism|
|proton-transporting ATPase activity, rotational mechanism|
|phagosome acidification|
|transferrin transport|
|phagosome maturation|
|intracellular pH reduction|
|pH reduction|
|azurophil granule membrane|
|ficolin-1-rich granule membrane|
|iron ion transport|
|phagocytic vesicle membrane|
|tertiary granule membrane|
|regulation of intracellular pH|
|insulin receptor signaling pathway|
|regulation of cellular pH|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|transition metal ion transport|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|cellular response to insulin stimulus|
|regulation of macroautophagy|
|positive regulation of Wnt signaling pathway|
|endosome membrane|
|response to insulin|
|cellular response to peptide hormone stimulus|
|ubiquitin protein ligase binding|
|lysosomal membrane|
|cellular response to peptide|
|regulation of autophagy|
|regulation of Wnt signaling pathway|
|response to peptide hormone|
|monovalent inorganic cation transport|
|focal adhesion|
|response to peptide|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|inorganic cation transmembrane transport|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|viral process|
|regulated exocytosis|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|leukocyte mediated immunity|
|symbiotic process|
|ion homeostasis|
|exocytosis|
|interspecies interaction between organisms|
|cation transport|
|regulation of cellular catabolic process|
|cellular homeostasis|
|response to hormone|
|leukocyte activation|
|ion transmembrane transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|secretion by cell|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|chemical homeostasis|
|secretion|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-3.08|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.61|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.61|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.49|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.32|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.29|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.25|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.18|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.09|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.01|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.98|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.95|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.92|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.86|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.82|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.79|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.78|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.78|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.77|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.75|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.71|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.74|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.79|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.81|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.88|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.89|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.18|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.644|
|[[:human genes:p:psmb4|PSMB4]]|0.555|
|[[:human genes:u:upf1|UPF1]]|0.513|
|[[:human genes:p:psma6|PSMA6]]|0.51|
|[[:human genes:t:ticrr|TICRR]]|0.501|
|[[:human genes:s:slc4a1|SLC4A1]]|0.497|
|[[:human genes:p:psmb3|PSMB3]]|0.494|
|[[:human genes:s:supt6h|SUPT6H]]|0.489|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.486|
|[[:human genes:p:prim1|PRIM1]]|0.486|
|[[:human genes:t:tceb3c|TCEB3C]]|0.484|
|[[:human genes:a:aatf|AATF]]|0.481|
|[[:human genes:c:chd4|CHD4]]|0.478|
|[[:human genes:p:polr2j|POLR2J]]|0.469|
|[[:human genes:s:supt5h|SUPT5H]]|0.469|
|[[:human genes:r:rrp7a|RRP7A]]|0.466|
|[[:human genes:p:psmd3|PSMD3]]|0.466|
|[[:human genes:k:krt78|KRT78]]|0.466|
|[[:human genes:s:slc38a7|SLC38A7]]|0.464|
|[[:human genes:r:rad51|RAD51]]|0.462|
|[[:human genes:p:pola1|POLA1]]|0.462|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.457|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.453|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.453|
|[[:human genes:z:znf830|ZNF830]]|0.453|
|[[:human genes:c:cbwd3|CBWD3]]|0.448|
|[[:human genes:w:wdr75|WDR75]]|0.446|
|[[:human genes:n:npipb5|NPIPB5]]|0.445|
|[[:human genes:o:osbp|OSBP]]|0.444|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.444|
|[[:human genes:i:iscu|ISCU]]|0.443|
|[[:human genes:c:copg1|COPG1]]|0.443|
|[[:human genes:c:col2a1|COL2A1]]|0.442|
|[[:human genes:c:clec11a|CLEC11A]]|0.441|
|[[:human genes:a:arcn1|ARCN1]]|0.441|
|[[:human genes:s:slc6a17|SLC6A17]]|0.44|
|[[:human genes:p:paf1|PAF1]]|0.439|
|[[:human genes:c:cdc45|CDC45]]|0.439|
|[[:human genes:n:nup205|NUP205]]|0.438|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.436|
|[[:human genes:i:ik|IK]]|0.435|
|[[:human genes:n:nup153|NUP153]]|0.435|
|[[:human genes:r:rpl35|RPL35]]|0.434|
|[[:human genes:f:fam231a|FAM231A]]|0.433|
|[[:human genes:c:cbwd6|CBWD6]]|0.433|
|[[:human genes:f:fam231c|FAM231C]]|0.433|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.433|
|[[:human genes:t:timeless|TIMELESS]]|0.432|
|[[:human genes:v:vasn|VASN]]|0.432|
|[[:human genes:c:copb1|COPB1]]|0.43|
|[[:human genes:o:orc6|ORC6]]|0.429|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.429|
|[[:human genes:r:rrn3|RRN3]]|0.428|
|[[:human genes:r:rps7|RPS7]]|0.428|
|[[:human genes:c:ccna2|CCNA2]]|0.428|
|[[:human genes:p:psmd7|PSMD7]]|0.427|
|[[:human genes:r:rps2|RPS2]]|0.426|
|[[:human genes:a:aqr|AQR]]|0.426|
|[[:human genes:e:exosc5|EXOSC5]]|0.425|
|[[:human genes:s:sema6b|SEMA6B]]|0.425|
|[[:human genes:p:psmd8|PSMD8]]|0.424|
|[[:human genes:p:phf2|PHF2]]|0.423|
|[[:human genes:p:polr1a|POLR1A]]|0.423|
|[[:human genes:n:npipb8|NPIPB8]]|0.422|
|[[:human genes:c:cbwd5|CBWD5]]|0.422|
|[[:human genes:t:twistnb|TWISTNB]]|0.421|
|[[:human genes:i:igfn1|IGFN1]]|0.419|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.419|
|[[:human genes:f:fbxo5|FBXO5]]|0.419|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.418|
|[[:human genes:r:riok2|RIOK2]]|0.418|
|[[:human genes:o:ogfr|OGFR]]|0.417|
|[[:human genes:v:vps52|VPS52]]|0.416|
|[[:human genes:n:nup160|NUP160]]|0.415|
|[[:human genes:o:orc1|ORC1]]|0.415|
|[[:human genes:c:cdca3|CDCA3]]|0.415|
|[[:human genes:p:polr2d|POLR2D]]|0.413|
|[[:human genes:a:ankle2|ANKLE2]]|0.412|
|[[:human genes:u:utp3|UTP3]]|0.41|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.41|
|[[:human genes:p:psmb2|PSMB2]]|0.408|
|[[:human genes:l:lrr1|LRR1]]|0.408|
|[[:human genes:h:hinfp|HINFP]]|0.407|
|[[:human genes:t:tyms|TYMS]]|0.405|
|[[:human genes:m:med14|MED14]]|0.405|
|[[:human genes:c:cope|COPE]]|0.405|
|[[:human genes:p:psap|PSAP]]|0.404|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.404|
|[[:human genes:p:plk1|PLK1]]|0.404|
|[[:human genes:n:napa|NAPA]]|0.404|
|[[:human genes:g:gid4|GID4]]|0.404|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.403|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.403|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.401|
|[[:human genes:s:snrnp70|SNRNP70]]|0.401|
|[[:human genes:b:bysl|BYSL]]|0.4|
|[[:human genes:v:vps28|VPS28]]|0.4|
|[[:human genes:t:taf15|TAF15]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 736/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP6V0C Expression in NALM6 Cells: 5.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>