======= ATP6V0D1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP6V0D1
  * **<color #00a2e8>Official Name</color>**: ATPase H+ transporting V0 subunit d1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9114|9114]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61421|P61421]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP6V0D1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP6V0D1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607028|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000250, ECO:0000269|PubMed:28296633}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|vATP-synt AC39|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plasma membrane proton-transporting V-type ATPase complex|
|proton-transporting V-type ATPase, V0 domain|
|cellular response to increased oxygen levels|
|vacuolar proton-transporting V-type ATPase complex|
|proton-exporting ATPase activity, phosphorylative mechanism|
|vacuolar acidification|
|proton-transporting ATPase activity, rotational mechanism|
|phagosome acidification|
|response to increased oxygen levels|
|transferrin transport|
|phagosome maturation|
|intracellular pH reduction|
|pH reduction|
|axon terminus|
|IRE1-mediated unfolded protein response|
|cellular iron ion homeostasis|
|iron ion transport|
|phagocytic vesicle membrane|
|iron ion homeostasis|
|regulation of intracellular pH|
|insulin receptor signaling pathway|
|regulation of cellular pH|
|regulation of pH|
|endoplasmic reticulum unfolded protein response|
|cellular transition metal ion homeostasis|
|cellular monovalent inorganic cation homeostasis|
|synaptic vesicle|
|transition metal ion transport|
|cellular response to unfolded protein|
|transition metal ion homeostasis|
|monovalent inorganic cation homeostasis|
|vacuolar transport|
|proton transmembrane transport|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|cellular response to insulin stimulus|
|regulation of macroautophagy|
|response to topologically incorrect protein|
|endosome membrane|
|cellular response to oxygen levels|
|response to insulin|
|early endosome|
|response to endoplasmic reticulum stress|
|cellular response to peptide hormone stimulus|
|protein-containing complex binding|
|lysosomal membrane|
|apical plasma membrane|
|cellular response to peptide|
|regulation of autophagy|
|cilium assembly|
|cilium organization|
|response to oxygen levels|
|response to peptide hormone|
|monovalent inorganic cation transport|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|response to peptide|
|centrosome|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|brain development|
|cellular chemical homeostasis|
|organelle assembly|
|head development|
|ion homeostasis|
|cation transport|
|regulation of cellular catabolic process|
|cellular homeostasis|
|response to hormone|
|ion transmembrane transport|
|central nervous system development|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|cellular response to stress|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.53|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.12|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.95|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.7|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.73|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.75|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.98|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.514|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|1/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1726
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP6V0D1 Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>