======= ATP6V1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP6V1A
  * **<color #00a2e8>Official Name</color>**: ATPase H+ transporting V1 subunit A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=523|523]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P38606|P38606]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP6V1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP6V1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607027|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:28296633}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt ab C|
|ATP-synt ab N|
|ATP-synt ab|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proton-transporting two-sector ATPase complex|
|proton-transporting V-type ATPase, V1 domain|
|cellular response to increased oxygen levels|
|proton-transporting ATPase activity, rotational mechanism|
|vacuolar membrane|
|phagosome acidification|
|response to increased oxygen levels|
|transferrin transport|
|phagosome maturation|
|intracellular pH reduction|
|pH reduction|
|cellular iron ion homeostasis|
|microvillus|
|iron ion transport|
|iron ion homeostasis|
|regulation of intracellular pH|
|insulin receptor signaling pathway|
|regulation of cellular pH|
|regulation of pH|
|cellular transition metal ion homeostasis|
|cellular monovalent inorganic cation homeostasis|
|transition metal ion transport|
|transition metal ion homeostasis|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|cellular response to insulin stimulus|
|regulation of macroautophagy|
|ATP metabolic process|
|cellular response to oxygen levels|
|response to insulin|
|cellular response to peptide hormone stimulus|
|lysosomal membrane|
|apical plasma membrane|
|cellular response to peptide|
|regulation of autophagy|
|response to oxygen levels|
|response to peptide hormone|
|monovalent inorganic cation transport|
|response to peptide|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|regulation of cellular catabolic process|
|cellular homeostasis|
|response to hormone|
|ion transmembrane transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|ATP binding|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-3.93|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-3.02|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.97|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.82|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.78|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.58|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.53|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-2.49|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.37|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.34|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.21|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.12|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.09|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.09|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.09|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.08|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.07|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.03|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.02|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.93|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.9|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.85|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.85|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.84|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.79|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.75|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.75|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.629|
|[[:human genes:p:polr2j3|POLR2J3]]|0.601|
|[[:human genes:p:prim1|PRIM1]]|0.559|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.534|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.531|
|[[:human genes:p:psmb4|PSMB4]]|0.527|
|[[:human genes:t:tceb3c|TCEB3C]]|0.522|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.521|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.513|
|[[:human genes:o:osbp|OSBP]]|0.513|
|[[:human genes:a:aatf|AATF]]|0.507|
|[[:human genes:s:sart1|SART1]]|0.5|
|[[:human genes:r:rrp7a|RRP7A]]|0.499|
|[[:human genes:s:slc6a17|SLC6A17]]|0.498|
|[[:human genes:t:trappc11|TRAPPC11]]|0.489|
|[[:human genes:c:copb1|COPB1]]|0.489|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.487|
|[[:human genes:k:krt78|KRT78]]|0.486|
|[[:human genes:u:upf1|UPF1]]|0.482|
|[[:human genes:t:tspy2|TSPY2]]|0.48|
|[[:human genes:t:tyms|TYMS]]|0.478|
|[[:human genes:s:strn|STRN]]|0.474|
|[[:human genes:t:tspy1|TSPY1]]|0.472|
|[[:human genes:c:chd4|CHD4]]|0.471|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.47|
|[[:human genes:p:psmb2|PSMB2]]|0.468|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.468|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.468|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.468|
|[[:human genes:t:ticrr|TICRR]]|0.459|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.459|
|[[:human genes:v:vps52|VPS52]]|0.456|
|[[:human genes:t:timeless|TIMELESS]]|0.456|
|[[:human genes:m:med14|MED14]]|0.455|
|[[:human genes:s:sf3a2|SF3A2]]|0.455|
|[[:human genes:r:rad51|RAD51]]|0.453|
|[[:human genes:p:psma6|PSMA6]]|0.453|
|[[:human genes:s:slc4a1|SLC4A1]]|0.453|
|[[:human genes:c:ctage4|CTAGE4]]|0.452|
|[[:human genes:a:atp6v1d|ATP6V1D]]|0.452|
|[[:human genes:a:aamp|AAMP]]|0.451|
|[[:human genes:c:copg1|COPG1]]|0.451|
|[[:human genes:c:copb2|COPB2]]|0.45|
|[[:human genes:c:cactin|CACTIN]]|0.449|
|[[:human genes:c:cbwd3|CBWD3]]|0.449|
|[[:human genes:w:wdr75|WDR75]]|0.444|
|[[:human genes:n:nipbl|NIPBL]]|0.444|
|[[:human genes:c:chmp4b|CHMP4B]]|0.443|
|[[:human genes:s:supt5h|SUPT5H]]|0.443|
|[[:human genes:n:nupl1|NUPL1]]|0.443|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.442|
|[[:human genes:r:rpl35|RPL35]]|0.44|
|[[:human genes:p:pole|POLE]]|0.44|
|[[:human genes:n:npipb5|NPIPB5]]|0.438|
|[[:human genes:v:vps54|VPS54]]|0.438|
|[[:human genes:l:lrrc56|LRRC56]]|0.438|
|[[:human genes:p:polr2j|POLR2J]]|0.438|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.437|
|[[:human genes:p:polr2j2|POLR2J2]]|0.437|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.437|
|[[:human genes:t:tsg101|TSG101]]|0.436|
|[[:human genes:i:ik|IK]]|0.434|
|[[:human genes:c:cep192|CEP192]]|0.432|
|[[:human genes:a:atp6v1h|ATP6V1H]]|0.431|
|[[:human genes:c:cbwd5|CBWD5]]|0.43|
|[[:human genes:c:chaf1a|CHAF1A]]|0.429|
|[[:human genes:c:cwc15|CWC15]]|0.428|
|[[:human genes:m:myb|MYB]]|0.427|
|[[:human genes:e:exosc3|EXOSC3]]|0.426|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.426|
|[[:human genes:e:exosc9|EXOSC9]]|0.425|
|[[:human genes:n:narfl|NARFL]]|0.425|
|[[:human genes:p:polr2a|POLR2A]]|0.425|
|[[:human genes:h:heatr1|HEATR1]]|0.424|
|[[:human genes:e:exosc8|EXOSC8]]|0.423|
|[[:human genes:n:nol12|NOL12]]|0.423|
|[[:human genes:i:iscu|ISCU]]|0.423|
|[[:human genes:s:syt9|SYT9]]|0.423|
|[[:human genes:r:rpl30|RPL30]]|0.423|
|[[:human genes:z:znf655|ZNF655]]|0.423|
|[[:human genes:t:trappc8|TRAPPC8]]|0.422|
|[[:human genes:x:xab2|XAB2]]|0.422|
|[[:human genes:e:exosc6|EXOSC6]]|0.422|
|[[:human genes:c:cdh24|CDH24]]|0.422|
|[[:human genes:s:sf3a3|SF3A3]]|0.422|
|[[:human genes:m:mt1e|MT1E]]|0.422|
|[[:human genes:c:copa|COPA]]|0.42|
|[[:human genes:c:cbwd6|CBWD6]]|0.419|
|[[:human genes:s:supt6h|SUPT6H]]|0.419|
|[[:human genes:c:cebpz|CEBPZ]]|0.418|
|[[:human genes:o:orc1|ORC1]]|0.418|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.417|
|[[:human genes:c:cdc45|CDC45]]|0.416|
|[[:human genes:r:rpl15|RPL15]]|0.415|
|[[:human genes:k:krt2|KRT2]]|0.414|
|[[:human genes:m:mfsd12|MFSD12]]|0.414|
|[[:human genes:c:copz1|COPZ1]]|0.413|
|[[:human genes:p:plxnb3|PLXNB3]]|0.413|
|[[:human genes:t:tfip11|TFIP11]]|0.413|
|[[:human genes:e:exosc5|EXOSC5]]|0.411|
|[[:human genes:z:znf541|ZNF541]]|0.411|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.41|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.41|
|[[:human genes:a:arcn1|ARCN1]]|0.41|
|[[:human genes:c:ctage9|CTAGE9]]|0.41|
|[[:human genes:t:tspy8|TSPY8]]|0.41|
|[[:human genes:r:rrp15|RRP15]]|0.409|
|[[:human genes:h:hinfp|HINFP]]|0.409|
|[[:human genes:d:ddtl|DDTL]]|0.408|
|[[:human genes:p:psmb3|PSMB3]]|0.407|
|[[:human genes:r:rpl9|RPL9]]|0.407|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.407|
|[[:human genes:c:ccna2|CCNA2]]|0.407|
|[[:human genes:d:dido1|DIDO1]]|0.407|
|[[:human genes:r:rpl3|RPL3]]|0.406|
|[[:human genes:p:pola1|POLA1]]|0.406|
|[[:human genes:d:dtl|DTL]]|0.406|
|[[:human genes:m:mdn1|MDN1]]|0.405|
|[[:human genes:u:utp3|UTP3]]|0.402|
|[[:human genes:m:mrs2|MRS2]]|0.401|
|[[:human genes:a:ankle1|ANKLE1]]|0.4|
|[[:human genes:m:mcoln1|MCOLN1]]|0.4|
|[[:human genes:c:cdc5l|CDC5L]]|0.4|
|[[:human genes:g:golga2|GOLGA2]]|0.4|
|[[:human genes:n:nol9|NOL9]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 727/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/26|
|breast|31/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 226
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP6V1A Expression in NALM6 Cells: 6.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>