======= ATP6V1C1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP6V1C1
  * **<color #00a2e8>Official Name</color>**: ATPase H+ transporting V1 subunit C1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=528|528]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21283|P21283]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP6V1C1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP6V1C1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603097|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-ATPase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vacuolar proton-transporting V-type ATPase, V1 domain|
|proton-transporting two-sector ATPase complex|
|proton-exporting ATPase activity, phosphorylative mechanism|
|proton-transporting ATPase activity, rotational mechanism|
|phagosome acidification|
|transferrin transport|
|transporter activity|
|phagosome maturation|
|intracellular pH reduction|
|pH reduction|
|iron ion transport|
|apical part of cell|
|regulation of intracellular pH|
|insulin receptor signaling pathway|
|regulation of cellular pH|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|transition metal ion transport|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|cellular response to insulin stimulus|
|regulation of macroautophagy|
|response to insulin|
|cytoplasmic vesicle|
|cellular response to peptide hormone stimulus|
|lysosomal membrane|
|cellular response to peptide|
|regulation of autophagy|
|response to peptide hormone|
|monovalent inorganic cation transport|
|response to peptide|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|inorganic cation transmembrane transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|regulation of cellular catabolic process|
|cellular homeostasis|
|response to hormone|
|ion transmembrane transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-2.07|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.91|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.84|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.83|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.75|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.576|
|[[:human genes:p:prim1|PRIM1]]|0.54|
|[[:human genes:p:psma6|PSMA6]]|0.536|
|[[:human genes:c:copg1|COPG1]]|0.534|
|[[:human genes:c:cdc6|CDC6]]|0.53|
|[[:human genes:f:fam25b|FAM25B]]|0.529|
|[[:human genes:t:tceb3c|TCEB3C]]|0.526|
|[[:human genes:s:sec13|SEC13]]|0.525|
|[[:human genes:c:cactin|CACTIN]]|0.523|
|[[:human genes:c:copb1|COPB1]]|0.518|
|[[:human genes:o:orc6|ORC6]]|0.517|
|[[:human genes:s:snrpa1|SNRPA1]]|0.517|
|[[:human genes:k:kctd17|KCTD17]]|0.516|
|[[:human genes:u:upf1|UPF1]]|0.515|
|[[:human genes:s:supt5h|SUPT5H]]|0.513|
|[[:human genes:t:tfip11|TFIP11]]|0.512|
|[[:human genes:s:sf3a2|SF3A2]]|0.512|
|[[:human genes:t:tsg101|TSG101]]|0.503|
|[[:human genes:p:pole|POLE]]|0.499|
|[[:human genes:c:cdca3|CDCA3]]|0.498|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.495|
|[[:human genes:r:rbm39|RBM39]]|0.494|
|[[:human genes:i:ik|IK]]|0.493|
|[[:human genes:s:stil|STIL]]|0.493|
|[[:human genes:m:mt1e|MT1E]]|0.491|
|[[:human genes:o:orc1|ORC1]]|0.49|
|[[:human genes:s:slc6a17|SLC6A17]]|0.488|
|[[:human genes:c:chd4|CHD4]]|0.487|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.487|
|[[:human genes:c:ccna2|CCNA2]]|0.486|
|[[:human genes:z:znf655|ZNF655]]|0.485|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.483|
|[[:human genes:z:znf541|ZNF541]]|0.482|
|[[:human genes:n:nupl1|NUPL1]]|0.482|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.482|
|[[:human genes:n:nup160|NUP160]]|0.478|
|[[:human genes:o:osbp|OSBP]]|0.478|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.477|
|[[:human genes:p:psmb2|PSMB2]]|0.477|
|[[:human genes:c:copz1|COPZ1]]|0.474|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.474|
|[[:human genes:c:cbwd6|CBWD6]]|0.473|
|[[:human genes:u:utp3|UTP3]]|0.472|
|[[:human genes:n:narfl|NARFL]]|0.471|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.47|
|[[:human genes:s:snrnp70|SNRNP70]]|0.47|
|[[:human genes:c:cbwd3|CBWD3]]|0.47|
|[[:human genes:b:brd2|BRD2]]|0.47|
|[[:human genes:s:slc4a1|SLC4A1]]|0.469|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.469|
|[[:human genes:e:exosc3|EXOSC3]]|0.469|
|[[:human genes:a:arcn1|ARCN1]]|0.469|
|[[:human genes:s:sap30bp|SAP30BP]]|0.465|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.465|
|[[:human genes:p:prpf19|PRPF19]]|0.465|
|[[:human genes:v:vps54|VPS54]]|0.464|
|[[:human genes:l:lrr1|LRR1]]|0.464|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.461|
|[[:human genes:c:cbwd5|CBWD5]]|0.461|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.46|
|[[:human genes:r:rpl35|RPL35]]|0.46|
|[[:human genes:c:ckap5|CKAP5]]|0.46|
|[[:human genes:v:vasn|VASN]]|0.46|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.459|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.458|
|[[:human genes:s:syt9|SYT9]]|0.458|
|[[:human genes:r:rrp15|RRP15]]|0.457|
|[[:human genes:p:psmd14|PSMD14]]|0.457|
|[[:human genes:p:psmd3|PSMD3]]|0.456|
|[[:human genes:d:dtl|DTL]]|0.456|
|[[:human genes:a:acsf2|ACSF2]]|0.456|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.452|
|[[:human genes:c:chaf1a|CHAF1A]]|0.452|
|[[:human genes:c:cdc45|CDC45]]|0.452|
|[[:human genes:n:napa|NAPA]]|0.451|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.451|
|[[:human genes:c:ctage4|CTAGE4]]|0.451|
|[[:human genes:p:psmb3|PSMB3]]|0.448|
|[[:human genes:o:or10g3|OR10G3]]|0.448|
|[[:human genes:r:rps12|RPS12]]|0.448|
|[[:human genes:e:eif4a3|EIF4A3]]|0.446|
|[[:human genes:t:tspy8|TSPY8]]|0.446|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.446|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.446|
|[[:human genes:n:npipb5|NPIPB5]]|0.446|
|[[:human genes:i:iscu|ISCU]]|0.445|
|[[:human genes:r:rplp1|RPLP1]]|0.444|
|[[:human genes:c:chmp4b|CHMP4B]]|0.444|
|[[:human genes:c:cep192|CEP192]]|0.443|
|[[:human genes:p:polr2j3|POLR2J3]]|0.442|
|[[:human genes:p:polr2a|POLR2A]]|0.442|
|[[:human genes:r:rad51|RAD51]]|0.441|
|[[:human genes:c:c14orf93|C14orf93]]|0.441|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.441|
|[[:human genes:r:rrp7a|RRP7A]]|0.441|
|[[:human genes:n:nsf|NSF]]|0.44|
|[[:human genes:p:psmc1|PSMC1]]|0.44|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.44|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.44|
|[[:human genes:z:znf148|ZNF148]]|0.438|
|[[:human genes:b:bysl|BYSL]]|0.438|
|[[:human genes:r:rps2|RPS2]]|0.435|
|[[:human genes:n:npipa7|NPIPA7]]|0.433|
|[[:human genes:g:gosr2|GOSR2]]|0.433|
|[[:human genes:n:npipa8|NPIPA8]]|0.433|
|[[:human genes:f:fam160a1|FAM160A1]]|0.432|
|[[:human genes:h:htatsf1|HTATSF1]]|0.432|
|[[:human genes:m:mms22l|MMS22L]]|0.431|
|[[:human genes:m:myo1h|MYO1H]]|0.431|
|[[:human genes:t:ticrr|TICRR]]|0.431|
|[[:human genes:c:cln6|CLN6]]|0.431|
|[[:human genes:p:pwp2|PWP2]]|0.431|
|[[:human genes:n:nbpf10|NBPF10]]|0.43|
|[[:human genes:t:timeless|TIMELESS]]|0.43|
|[[:human genes:p:psmd7|PSMD7]]|0.428|
|[[:human genes:s:strn|STRN]]|0.428|
|[[:human genes:n:nol10|NOL10]]|0.427|
|[[:human genes:e:exosc4|EXOSC4]]|0.427|
|[[:human genes:k:krt78|KRT78]]|0.427|
|[[:human genes:n:nup85|NUP85]]|0.427|
|[[:human genes:m:myb|MYB]]|0.427|
|[[:human genes:e:exosc5|EXOSC5]]|0.426|
|[[:human genes:s:snx15|SNX15]]|0.426|
|[[:human genes:d:ddt|DDT]]|0.425|
|[[:human genes:e:exosc6|EXOSC6]]|0.425|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.424|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.423|
|[[:human genes:z:znf830|ZNF830]]|0.422|
|[[:human genes:d:ddtl|DDTL]]|0.422|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.421|
|[[:human genes:t:twistnb|TWISTNB]]|0.421|
|[[:human genes:t:tuba8|TUBA8]]|0.421|
|[[:human genes:c:ctage9|CTAGE9]]|0.421|
|[[:human genes:c:cdc73|CDC73]]|0.42|
|[[:human genes:r:rnf113a|RNF113A]]|0.42|
|[[:human genes:r:rad21|RAD21]]|0.419|
|[[:human genes:d:dido1|DIDO1]]|0.419|
|[[:human genes:r:rpl30|RPL30]]|0.419|
|[[:human genes:p:ppie|PPIE]]|0.419|
|[[:human genes:c:cope|COPE]]|0.418|
|[[:human genes:s:sf3a1|SF3A1]]|0.418|
|[[:human genes:g:golga8j|GOLGA8J]]|0.417|
|[[:human genes:p:plekha4|PLEKHA4]]|0.417|
|[[:human genes:s:samd1|SAMD1]]|0.417|
|[[:human genes:m:mylk3|MYLK3]]|0.416|
|[[:human genes:i:igfn1|IGFN1]]|0.416|
|[[:human genes:t:trappc11|TRAPPC11]]|0.416|
|[[:human genes:t:tyms|TYMS]]|0.415|
|[[:human genes:a:aatf|AATF]]|0.413|
|[[:human genes:p:psma7|PSMA7]]|0.413|
|[[:human genes:a:akirin2|AKIRIN2]]|0.412|
|[[:human genes:r:rrm2|RRM2]]|0.412|
|[[:human genes:s:sf3a3|SF3A3]]|0.412|
|[[:human genes:n:nipbl|NIPBL]]|0.412|
|[[:human genes:p:pola2|POLA2]]|0.411|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.411|
|[[:human genes:n:nufip2|NUFIP2]]|0.41|
|[[:human genes:c:copb2|COPB2]]|0.409|
|[[:human genes:o:ogfr|OGFR]]|0.409|
|[[:human genes:d:dock6|DOCK6]]|0.409|
|[[:human genes:s:setd1a|SETD1A]]|0.408|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.408|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.408|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.408|
|[[:human genes:a:acd|ACD]]|0.407|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.407|
|[[:human genes:t:trappc8|TRAPPC8]]|0.407|
|[[:human genes:r:rrn3|RRN3]]|0.404|
|[[:human genes:p:psmd2|PSMD2]]|0.404|
|[[:human genes:s:sult2b1|SULT2B1]]|0.404|
|[[:human genes:t:tpx2|TPX2]]|0.404|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.403|
|[[:human genes:p:plrg1|PLRG1]]|0.403|
|[[:human genes:x:xylt2|XYLT2]]|0.403|
|[[:human genes:c:csnk1a1|CSNK1A1]]|0.403|
|[[:human genes:c:cdc5l|CDC5L]]|0.402|
|[[:human genes:t:traip|TRAIP]]|0.402|
|[[:human genes:p:plk4|PLK4]]|0.402|
|[[:human genes:r:rpp40|RPP40]]|0.402|
|[[:human genes:p:polr2f|POLR2F]]|0.401|
|[[:human genes:s:ssh2|SSH2]]|0.401|
|[[:human genes:r:rnpc3|RNPC3]]|0.401|
|[[:human genes:a:aqr|AQR]]|0.4|
|[[:human genes:s:supt6h|SUPT6H]]|0.4|
|[[:human genes:f:fcn2|FCN2]]|0.4|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 84/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|2/28|
|bone|4/26|
|breast|2/33|
|central nervous system|3/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|1/1|
|gastric|0/16|
|kidney|7/21|
|liver|3/20|
|lung|11/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|4/24|
|peripheral nervous system|3/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 955
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP6V1C1 Expression in NALM6 Cells: 6.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>