======= ATP6V1G1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP6V1G1
  * **<color #00a2e8>Official Name</color>**: ATPase H+ transporting V1 subunit G1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9550|9550]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75348|O75348]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP6V1G1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP6V1G1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607296|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:28296633}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-ATPase G|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vacuolar proton-transporting V-type ATPase complex|
|proton-exporting ATPase activity, phosphorylative mechanism|
|cellular response to increased oxygen levels|
|response to increased oxygen levels|
|phagosome acidification|
|transferrin transport|
|phagosome maturation|
|intracellular pH reduction|
|pH reduction|
|ATPase-coupled transmembrane transporter activity|
|cellular iron ion homeostasis|
|iron ion transport|
|ATPase binding|
|iron ion homeostasis|
|regulation of intracellular pH|
|insulin receptor signaling pathway|
|regulation of cellular pH|
|regulation of pH|
|cellular transition metal ion homeostasis|
|cellular monovalent inorganic cation homeostasis|
|transition metal ion transport|
|transition metal ion homeostasis|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|cellular response to insulin stimulus|
|regulation of macroautophagy|
|cellular response to oxygen levels|
|response to insulin|
|ATPase activity|
|cellular response to peptide hormone stimulus|
|lysosomal membrane|
|cellular response to peptide|
|regulation of autophagy|
|response to oxygen levels|
|response to peptide hormone|
|monovalent inorganic cation transport|
|response to peptide|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|regulation of cellular catabolic process|
|cellular homeostasis|
|response to hormone|
|ion transmembrane transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp169|BH1 1μM R04 exp169]]|-3.11|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.49|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.46|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.4|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.16|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-2.16|
|[[:results:exp136|MS094 2μM R03 exp136]]|-2.08|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.99|
|[[:results:exp539|42°C R08 exp539]]|-1.95|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.91|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.89|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.89|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.73|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.72|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.71|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.7|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.79|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.83|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wdr7|WDR7]]|0.49|
|[[:human genes:s:scap|SCAP]]|0.459|
|[[:human genes:a:atp6v0a2|ATP6V0A2]]|0.43|
|[[:human genes:m:mbtps1|MBTPS1]]|0.42|
|[[:human genes:z:zfat|ZFAT]]|0.405|
|[[:human genes:a:arl1|ARL1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 668/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|20/26|
|breast|31/33|
|central nervous system|45/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|19/20|
|lung|64/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|7/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2841
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP6V1G1 Expression in NALM6 Cells: 5.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>